Drug profile

The FDA adverse-event record for Cefovecin

9,007 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Cefovecin. See the species affected, top reactions, and outcomes below.

9,007
adverse-event reports
20.4%
death-coded share
Cat
most-reported species
1,758
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
9,007
Total Reports
1,833
Deaths Reported
20.4%
Death Rate

Active Ingredients

Cefovecin

Administration Routes

SubcutaneousUnknownIntravenousParenteralOtherIntramuscularSubconjunctivalOphthalmicTopicalOral

Species Affected

Cat 5,411
Dog 2,755
Unknown 798
Human 29
Guinea Pig 3
Other Rodents 2
Ferret 2
Rabbit 2
Other 2
Other Canids 1

Most Affected Breeds

Domestic Shorthair 3,307
Unknown 840
Domestic Longhair 464
Cat (other) 419
Domestic Mediumhair 285
Chihuahua 234
Terrier - Yorkshire 217
Siamese 188
Cat (unknown) 185
Shih Tzu 168

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 1,758
Vomiting 1,298
Anorexia 1,195
Death 1,012
Death by euthanasia 719
Diarrhoea 665
Weight loss 635
Other abnormal test result NOS 589
Fever 580
Not eating 539
Lack of efficacy - NOS 538
Seizure NOS 536

Outcome Breakdown

Ongoing
4,039 (49.1%)
Outcome Unknown
1,269 (15.4%)
Died
1,116 (13.6%)
Recovered/Normal
1,071 (13.0%)
Euthanized
718 (8.7%)
Recovered with Sequela
13 (0.2%)

Cefovecin Adverse Event Insights

9,007 reports name Cefovecin; 1,833 recorded a death outcome (20.4% of reported events, not a population-level mortality rate). Active ingredient: Cefovecin. Administration routes: Subcutaneous, Unknown, Intravenous, Parenteral.

By species: Cat (5,411 reports), Dog (2,755 reports), Unknown (798 reports). By breed: Domestic Shorthair (3,307), Unknown (840), Domestic Longhair (464).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (1,758), Vomiting (1,298), Anorexia (1,195), Death (1,012). Outcome, 8,226 coded reports: Ongoing leads at 49.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.