Drug profile

The FDA adverse-event record for Carprofen

23,400 FDA reports name Carprofen, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#12 of 2,679
by report volume (all drugs)
23,400
adverse-event reports
15.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Carprofen ranks #12 of 2679 by total reports (23,400) and #361 of 1130 by death-coded share (15.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#12
This drug, reports of 2679
#361
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Carprofen has 23,400 reports now versus 23,033 in that prior snapshot: 367 more (1.6%).

Report change
+367
Death-coded reports
+68
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Carprofen changes

Signature read: death-coded report count at 3,529 is the most distinctive stamp on Carprofen's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
23,400
Total Reports
3,529
Deaths Reported
15.1%
Death-coded share of reports

Active Ingredients

Carprofen

Administration Routes

OralUnknownSubcutaneousParenteralOphthalmicIntravenousIntramuscularTopicalOtherSubconjunctival

Species Affected

Dog 21,250
Unknown 1,876
Cat 193
Human 60
Mouse 6
Rat 4
Other 2
Other Rodents 2
Monkey 2
Guinea Pig 1

Most Affected Breeds

Retriever - Labrador 4,429
Unknown 2,034
Crossbred Canine/dog 1,244
Retriever - Golden 1,148
Shepherd Dog - German 956
Dog (unknown) 808
Boxer (German Boxer) 537
Terrier - Bull - American Pit 509
Chihuahua 444
Beagle 427

Most Reported Reactions

Vomiting 5,550
Anorexia 3,327
Elevated alanine aminotransferase (ALT) 3,218
Lethargy (see also Central nervous system depression in 'Neurological') 2,793
Diarrhoea 2,781
Elevated serum alkaline phosphatase (SAP) 2,370
Death by euthanasia 2,023
Elevated total bilirubin 1,730
Other abnormal test result NOS 1,465
Death 1,395
Weight loss 1,358
Elevated liver enzymes 1,332

Outcome Breakdown

Ongoing
7,783 (40.8%)
Recovered/Normal
4,312 (22.6%)
Outcome Unknown
3,263 (17.1%)
Died
1,791 (9.4%)
Euthanized
1,738 (9.1%)
Recovered with Sequela
181 (0.9%)

Carprofen: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Carprofen, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (15.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Carprofen (#12 of 2,679 by report volume); death-coded 15.1%. PlainBreed drug row · death-coded report count stamp 3,529 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →