Reaction profile

The FDA adverse-event record for pr-bone(s), lesion(s)

Name: PR-BONE(S), LESION(S) - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

24 FDA reports name pr-bone(s), lesion(s), a lower-volume reaction in the CVM extract (VeDDRA 99594). Plate stamps and neighbourhood peers follow.

#2091 of 2,481
by report volume (all reactions): 24
reports citing this reaction: 66.7%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. PR-BONE(S), LESION(S) has 24 reports now versus 24 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to PR-BONE(S), LESION(S) changes

FDA AER · VeDDRA plate

Code 99594 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 24 reports
DEATH-HOT 66.7%
LOWER-Q #2091/2481
PHOTO-FINISH Acute pancreatitis
SPECIES-DOG Dog · 13
DRUG-LEAD Oclacitinib Malea… · 4
DESK-WIDE 18 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Acute pancreatitis (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around PR-BONE, LESION

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around PR-BONE(S), LESION(S)

PR-BONE(S), LESION(S): high death-coded share in the FDA AER plate

Signature read: PR-BONE(S), LESION(S)'s 66.7% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 24 named reports in the openFDA extract. Death-coded share is upper-third: 16 of 24 reports (66.7% of named reports). Nearest volume peer: Acute pancreatitis (±0 reports). Lead species Dog (13). Lead co-reported drug Oclacitinib Maleate (4).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 13

Horse 7

Cat 3

Cattle 1

Breeds Most Affected

Crossbred Canine/dog 3

Retriever - Labrador 3

Appaloosa 2

Quarter Horse 2

Terrier - Yorkshire 1

Pointer (unspecified) 1

Domestic (unspecified) 1

Cattle (other) 1

Chihuahua 1

Hanovarian 1

Associated Drugs

Oclacitinib Maleate 4

Carprofen 3

Xylazine 2

Maropitant Citrate 2

Ceftiofur Crystalline Free Acid 2

Polysulfated Glycosaminoglycan 2

Methylprednisolone Acetate 2

Amoxicillin, Clavulanate 1

Toceranib Phosphate 1

Deracoxib 1

Cefovecin Sodium 1

Gamithromycin 1

Milbemycin 1

Sulfadimethoxine 1

Flea/Heartworm Preventative 1

Vaccines 1

Detomidine 1

Eastern Equine Encephalomyelitis; Venezuelan Equine Encephalomyelitis; Western E 1

Clodronate Disodium 1

Flunixin Meglumine 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for PR-BONE(S), LESION(S) (#2091 of 2,481 by report volume); death-coded 66.7%. PlainBreed reaction plate · death-coded share stamp 66.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →