Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - anaplasma nos

Name: Lack of efficacy (bacteria) - Anaplasma NOS - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

38 FDA reports name lack of efficacy (bacteria) - anaplasma nos, a lower-volume reaction in the CVM extract (VeDDRA 2991). Plate stamps and neighbourhood peers follow.

#1877 of 2,481
by report volume (all reactions): 38
reports citing this reaction: 0.0%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (bacteria) - Anaplasma NOS has 38 reports now versus 38 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (bacteria) - Anaplasma NOS changes

FDA AER · VeDDRA plate

Code 2991 VOL-TRACE

VOL-TRACE · DEATH-RARE · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 38 reports
DEATH-RARE 0.0%
LOWER-Q #1877/2481
PHOTO-FINISH Clenched jaw
SPECIES-DOG Dog · 38
DRUG-LEAD Afoxolaner · 22
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Clenched jaw (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Lack of efficacy - Anaplasma NOS

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Lack of efficacy (bacteria) - Anaplasma NOS

Lack of efficacy (bacteria) - Anaplasma NOS: low death-coded share in the FDA AER plate

Signature read: Lack of efficacy (bacteria) - Anaplasma NOS's 0.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is lower-third scale: 38 named reports in the openFDA extract. Death-coded share is lower-third: 0 of 38 reports (0.0% of named reports). Nearest volume peer: Clenched jaw (±0 reports). Lead species Dog (38). Lead co-reported drug Afoxolaner (22).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 38

Breeds Most Affected

Dog (unknown) 5

Retriever - Golden 4

Retriever - Labrador 3

Spaniel (unspecified) 3

Crossbred Canine/dog 2

Shepherd Dog - German 2

Shih Tzu 2

Shepherd Dog (unspecified) 2

Spitz - German Pomeranian 2

Alaskan Malamute 2

Associated Drugs

Afoxolaner 22

Pyrantel Pamoate;Sarolaner 10

Lotilaner 10

Milbemycin Oxime + Praziquantel 6

Recombitek Lyme - 2126.R0 3

Borrelia Burgdorferi Bacterin 3

Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 2

Fluralaner 13.64% 12-Week Chew 1

Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 1

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 1

Leptospira-Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1

Sarolaner 1

Bordetella Vaccine 1

Milbemycin Oxime, Praziquantel 1

Ivermectin + Pyrantel As Pamoate Salt 1

Unknown Manufacturer Lyme 1

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (bacteria) - Anaplasma NOS (#1877 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →