Zonisamide
289 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
289
Total Reports
42
Deaths Reported
1450.0%
Death Rate
Active Ingredients
Zonisamide
Administration Routes
OralUnknown
Species Affected
Dog 280
Cat 8
Human 1
Most Affected Breeds
Retriever - Labrador 31
Dog (unknown) 21
Shih Tzu 14
Chihuahua 12
Shepherd Dog - Australian 12
Siberian Husky 10
Shepherd Dog - German 8
Crossbred Canine/dog 8
Maltese 7
Dachshund (unspecified) 6
Most Reported Reactions
Seizure NOS 107
Vomiting 40
Lethargy (see also Central nervous system depression in 'Neurological') 31
Death by euthanasia 26
Diarrhoea 24
Ataxia 22
Lethargy (see also Central nervous system depression in Neurological) 20
Lack of efficacy - NOS 18
Anorexia 15
Other abnormal test result NOS 15
Elevated alanine aminotransferase (ALT) 15
Not eating 15
Outcome Breakdown
Ongoing
89 (31.2%)
Recovered/Normal
85 (29.8%)
Outcome Unknown
66 (23.2%)
Euthanized
26 (9.1%)
Died
16 (5.6%)
Recovered with Sequela
3 (1.1%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.