Drug profile

The FDA adverse-event record for Zilpaterol Oral Powder

11 FDA reports name Zilpaterol Oral Powder, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2534 of 2,679
by report volume (all drugs)
11
adverse-event reports
72.7%
death-coded share
Cattle
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Zilpaterol Oral Powder ranks #2412 of 2679 by total reports (11). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2412
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Zilpaterol Oral Powder has 11 reports now versus 11 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Zilpaterol Oral Powder changes

Signature read: Zilpaterol Oral Powder's 72.7% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
11
Total Reports
8
Deaths Reported
72.7%
Death-coded share of reports

Active Ingredients

Zilpaterol Oral Powder

Administration Routes

OralUnknown

Species Affected

Cattle 7
Dog 2
Human 1
Horse 1

Most Affected Breeds

Cattle (other) 3
Crossbred Bovine/Cattle 3
Unknown 1
Cattle (unspecified) 1
Bulldog - French 1
Crossbred Canine/dog 1
Crossbred Equine/horse 1

Most Reported Reactions

Death by euthanasia 5
Death 3
Unclassifiable adverse event 2
Lameness 2
Other abnormal test result NOS 2
Trauma NOS 2
Tachycardia 2
Unrelated death 1
Hair coat discolouration 1
Ruminal bloat 1
NT - Abnormal necropsy finding NOS 1
Fracture 1

Outcome Breakdown

Euthanized
6 (42.9%)
Outcome Unknown
3 (21.4%)
Died
3 (21.4%)
Recovered/Normal
1 (7.1%)
Ongoing
1 (7.1%)

Zilpaterol Oral Powder: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Zilpaterol Oral Powder (#2534 of 2,679 by report volume); death-coded 72.7%. PlainBreed drug row · death-coded share stamp 72.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →