Drug profile

The FDA adverse-event record for Yohimbine

17 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Yohimbine. See the species affected, top reactions, and outcomes below.

17
adverse-event reports
41.2%
death-coded share
Dog
most-reported species
5
Death - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
17
Total Reports
7
Deaths Reported
41.2%
Death Rate

Active Ingredients

Yohimbine

Administration Routes

UnknownParenteralIntravenousSubcutaneousIntramuscular

Species Affected

Dog 8
Cat 7
Other Birds 1
Mouse 1

Most Affected Breeds

Domestic Shorthair 3
Retriever - Labrador 2
Crossbred Canine/dog 2
Dachshund (unspecified) 2
Cat (unknown) 2
Other Birds (other) 1
Unknown 1
Domestic Longhair 1
Mixed (Cat) 1
Pit Bull 1

Most Reported Reactions

Death 5
Lethargy (see also Central nervous system depression in 'Neurological') 5
Emesis 4
Other abnormal test result NOS 3
Hives (see also 'Skin') 3
Tachycardia 2
Recumbency 2
Fever 2
Death by euthanasia 2
Sedation 2
Seizure NOS 2
Hyperthermia 2

Outcome Breakdown

Recovered/Normal
11 (61.1%)
Died
6 (33.3%)
Euthanized
1 (5.6%)

Yohimbine Adverse Event Insights

17 reports name Yohimbine; 7 recorded a death outcome (41.2% of reported events, not a population-level mortality rate). Active ingredient: Yohimbine. Administration routes: Unknown, Parenteral, Intravenous, Subcutaneous.

By species: Dog (8 reports), Cat (7 reports), Other Birds (1 reports). By breed: Domestic Shorthair (3), Retriever - Labrador (2), Crossbred Canine/dog (2).

Leading clinical signs: Death (5), Lethargy (see also Central nervous system depression in 'Neurological') (5), Emesis (4), Other abnormal test result NOS (3). Outcome, 18 coded reports: Recovered/Normal leads at 61.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.