Vitamin K

Vitamin K Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 72 adverse event reports referencing Vitamin K, including 35 reports in which the animal died — a 4860.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Vitamin K. Reported administration routes include Unknown, Oral, Subcutaneous, Intramuscular. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Vitamin K reports are Dog (54 reports), Cat (13 reports), Other Birds (3 reports), with Dog accounting for the largest share. Within those species, Retriever - Labrador (14), Domestic Shorthair (10), Shepherd Dog - German (3) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Vitamin K are Death (20), Vomiting (17), Lethargy (see also Central nervous system depression in 'Neurological') (15), Death by euthanasia (15). Of the 72 reports with a coded outcome, Died is the leading category at 27.8%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Vitamin K.