Drug profile

The FDA adverse-event record for Vitamin K

72 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Vitamin K. See the species affected, top reactions, and outcomes below.

72
adverse-event reports
48.6%
death-coded share
Dog
most-reported species
20
Death - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
72
Total Reports
35
Deaths Reported
48.6%
Death Rate

Active Ingredients

Vitamin K

Administration Routes

UnknownOralSubcutaneousIntramuscularParenteralIntravenous

Species Affected

Dog 54
Cat 13
Other Birds 3
Horse 1
Cattle 1

Most Affected Breeds

Retriever - Labrador 14
Domestic Shorthair 10
Shepherd Dog - German 3
Unknown 3
Retriever - Golden 3
Terrier - Bull - American Pit 3
Corgi - Welsh Pembroke 3
Crossbred Canine/dog 2
Rottweiler 2
Turkish Angora 2

Most Reported Reactions

Death 20
Vomiting 17
Lethargy (see also Central nervous system depression in 'Neurological') 15
Death by euthanasia 15
Elevated total bilirubin 14
Elevated alanine aminotransferase (ALT) 14
Other abnormal test result NOS 13
Abnormal ultrasound finding 12
Anaemia NOS 10
Anorexia 10
Icterus 10
Not eating 10

Outcome Breakdown

Died
20 (27.8%)
Ongoing
16 (22.2%)
Euthanized
15 (20.8%)
Recovered/Normal
11 (15.3%)
Outcome Unknown
10 (13.9%)

Vitamin K Adverse Event Insights

72 reports name Vitamin K; 35 recorded a death outcome (48.6% of reported events, not a population-level mortality rate). Active ingredient: Vitamin K. Administration routes: Unknown, Oral, Subcutaneous, Intramuscular.

By species: Dog (54 reports), Cat (13 reports), Other Birds (3 reports). By breed: Retriever - Labrador (14), Domestic Shorthair (10), Shepherd Dog - German (3).

Leading clinical signs: Death (20), Vomiting (17), Lethargy (see also Central nervous system depression in 'Neurological') (15), Death by euthanasia (15). Outcome, 72 coded reports: Died leads at 27.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.