Drug profile

The FDA adverse-event record for Vitamin D

51 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Vitamin D. Species, reactions, and outcomes follow.

#1119 of 2,679
by report volume (all drugs)
51
adverse-event reports
9.8%
death-coded share
Human
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Vitamin D ranks #1098 of 2679 by total reports (51) and #554 of 1130 by death-coded share (9.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1098
This drug, reports of 2679
#554
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vitamin D has 51 reports now versus 47 in that prior snapshot: 4 more (8.5%).

Report change
+4
Death-coded reports
+0
Death-coded share
−0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vitamin D changes

Signature read: report volume at 51 is the most distinctive stamp on Vitamin D's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
51
Total Reports
5
Deaths Reported
9.8%
Death-coded share of reports

Active Ingredients

Vitamin D

Administration Routes

UnknownOral

Species Affected

Human 38
Dog 8
Cat 2
Llama 1
Pig 1
Cattle 1

Most Affected Breeds

Unknown 39
Domestic Shorthair 2
Schnauzer (unspecified) 2
Shepherd Dog - German 1
Pig (unknown) 1
Mixed (Cattle) 1
Terrier - American Staffordshire 1
Terrier - Cairn 1
Terrier - Silky 1
Retriever - Labrador 1

Most Reported Reactions

Accidental exposure 20
Diarrhoea 6
Headache 5
Dizziness 5
Lethargy (see also Central nervous system depression in 'Neurological') 4
Not eating 4
Nausea 3
Mental impairment NOS 3
Vocalisation 3
Seizure NOS 3
Death 2
Anorexia 2

Outcome Breakdown

Recovered/Normal
24 (45.3%)
Outcome Unknown
17 (32.1%)
Ongoing
7 (13.2%)
Died
3 (5.7%)
Euthanized
2 (3.8%)

Vitamin D Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Nationwide drugs with similar profiles

Two openFDA-derived peer sets for Vitamin D, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (9.8% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vitamin D (#1119 of 2,679 by report volume); death-coded 9.8%. PlainBreed drug row · report volume stamp 51 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →