Drug profile

The FDA adverse-event record for Vitamin B 12

16 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Vitamin B 12. See the species affected, top reactions, and outcomes below.

16
adverse-event reports
31.3%
death-coded share
Cat
most-reported species
6
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
16
Total Reports
5
Deaths Reported
31.3%
Death Rate

Active Ingredients

Vitamin B 12

Administration Routes

UnknownSubcutaneousParenteralIntravenous

Species Affected

Cat 8
Dog 6
Cattle 1
Horse 1

Most Affected Breeds

Domestic Longhair 3
Domestic Shorthair 3
Shepherd Dog - German 1
Terrier - Irish Soft-coated Wheaten 1
Cattle (other) 1
Maltese 1
Cat (other) 1
Domestic Mediumhair 1
Terrier - Rat 1
Bulldog - French 1

Most Reported Reactions

Vomiting 6
Ataxia 4
Anorexia 4
Diarrhoea 4
Death by euthanasia 3
Weight loss 3
Elevated renal parameters 2
Renal failure 2
Death 2
Loose stool 2
Nausea 2
Bacterial skin infection NOS 1

Outcome Breakdown

Ongoing
5 (31.3%)
Euthanized
3 (18.8%)
Recovered/Normal
3 (18.8%)
Outcome Unknown
3 (18.8%)
Died
2 (12.5%)

Vitamin B 12 Adverse Event Insights

16 reports name Vitamin B 12; 5 recorded a death outcome (31.3% of reported events, not a population-level mortality rate). Active ingredient: Vitamin B 12. Administration routes: Unknown, Subcutaneous, Parenteral, Intravenous.

By species: Cat (8 reports), Dog (6 reports), Cattle (1 reports). By breed: Domestic Longhair (3), Domestic Shorthair (3), Shepherd Dog - German (1).

Leading clinical signs: Vomiting (6), Ataxia (4), Anorexia (4), Diarrhoea (4). Outcome, 16 coded reports: Ongoing leads at 31.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.