Drug profile

The FDA adverse-event record for Vetprofen

98 FDA reports name Vetprofen, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#790 of 2,679
by report volume (all drugs)
98
adverse-event reports
21.4%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Vetprofen ranks #784 of 2679 by total reports (98) and #217 of 1130 by death-coded share (21.4%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#784
This drug, reports of 2679
#217
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vetprofen has 98 reports now versus 98 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vetprofen changes

Signature read: death-coded report count at 21 is the most distinctive stamp on Vetprofen's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
98
Total Reports
21
Deaths Reported
21.4%
Death-coded share of reports

Active Ingredients

Vetprofen

Administration Routes

UnknownOral

Species Affected

Dog 98

Most Affected Breeds

Retriever - Labrador 15
Crossbred Canine/dog 9
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 7
Shepherd Dog - German 5
Dog (unknown) 4
Terrier - Bull - American Pit 4
Beagle 3
Shepherd Dog - Australian 3
Retriever - Golden 3
Boxer (German Boxer) 3

Most Reported Reactions

Lethargy (see also Central nervous system depression in Neurological) 12
Death by euthanasia 12
Ataxia 11
Limb weakness 11
Vomiting 9
Unable to walk 9
Death 9
Medication error NOS 9
Urinary tract infection 8
Diarrhoea 7
Weight loss 7
Proprioception deficit 7

Outcome Breakdown

Ongoing
58 (59.2%)
Euthanized
12 (12.2%)
Outcome Unknown
10 (10.2%)
Recovered/Normal
9 (9.2%)
Died
9 (9.2%)

Vetprofen: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Vetprofen, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (21.4% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vetprofen (#790 of 2,679 by report volume); death-coded 21.4%. PlainBreed drug row · death-coded report count stamp 21 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →