Drug profile

The FDA adverse-event record for Verdinexor

605 FDA reports name Verdinexor, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#267 of 2,679
by report volume (all drugs)
605
adverse-event reports
38.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Verdinexor ranks #267 of 2679 by total reports (605) and #86 of 1130 by death-coded share (38.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#267
This drug, reports of 2679
#86
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Verdinexor has 605 reports now versus 593 in that prior snapshot: 12 more (2.0%).

Report change
+12
Death-coded reports
+2
Death-coded share
−0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Verdinexor changes

Signature read: death-coded report count at 232 is the most distinctive stamp on Verdinexor's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
605
Total Reports
232
Deaths Reported
38.3%
Death-coded share of reports

Active Ingredients

Verdinexor

Administration Routes

OralUnknownTopical

Species Affected

Dog 602
Human 3

Most Affected Breeds

Retriever - Labrador 83
Retriever - Golden 50
Dog (unknown) 44
American Pit Bull Terrier 40
Beagle 26
Crossbred Canine/dog 23
Collie - Border 20
Shih Tzu 16
Boxer (German Boxer) 16
Terrier (unspecified) 14

Most Reported Reactions

Vomiting 167
Death by euthanasia 167
Weight loss 148
Diarrhoea 111
Lack of efficacy - NOS 100
Decreased appetite 98
Elevated alanine aminotransferase (ALT) 97
Thrombocytopenia 83
Anorexia 72
Elevated serum alkaline phosphatase (SAP) 67
Lethargy (see also Central nervous system depression in 'Neurological') 61
Death 60

Outcome Breakdown

Outcome Unknown
239 (39.5%)
Euthanized
169 (27.9%)
Ongoing
72 (11.9%)
Died
63 (10.4%)
Recovered/Normal
60 (9.9%)
Recovered with Sequela
2 (0.3%)

Verdinexor: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Verdinexor, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Verdinexor (#267 of 2,679 by report volume); death-coded 38.3%. PlainBreed drug row · death-coded report count stamp 232 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →