Drug profile

The FDA adverse-event record for Verdinexor

579 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Verdinexor. See the species affected, top reactions, and outcomes below.

579
adverse-event reports
38.9%
death-coded share
Dog
most-reported species
162
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
579
Total Reports
225
Deaths Reported
38.9%
Death Rate

Active Ingredients

Verdinexor

Administration Routes

OralUnknownTopical

Species Affected

Dog 576
Human 3

Most Affected Breeds

Retriever - Labrador 77
Retriever - Golden 48
Dog (unknown) 41
American Pit Bull Terrier 40
Beagle 26
Crossbred Canine/dog 22
Collie - Border 17
Shih Tzu 16
Boxer (German Boxer) 15
Shepherd Dog - German 13

Most Reported Reactions

Vomiting 162
Death by euthanasia 161
Weight loss 146
Diarrhoea 108
Lack of efficacy - NOS 98
Decreased appetite 93
Elevated alanine aminotransferase (ALT) 91
Thrombocytopenia 77
Anorexia 70
Elevated serum alkaline phosphatase (SAP) 67
Lethargy (see also Central nervous system depression in 'Neurological') 61
Death 59

Outcome Breakdown

Outcome Unknown
225 (38.9%)
Euthanized
163 (28.2%)
Ongoing
72 (12.4%)
Died
62 (10.7%)
Recovered/Normal
55 (9.5%)
Recovered with Sequela
2 (0.3%)

Verdinexor Adverse Event Insights

579 reports name Verdinexor; 225 recorded a death outcome (38.9% of reported events, not a population-level mortality rate). Active ingredient: Verdinexor. Administration routes: Oral, Unknown, Topical.

By species: Dog (576 reports), Human (3 reports). By breed: Retriever - Labrador (77), Retriever - Golden (48), Dog (unknown) (41).

Leading clinical signs: Vomiting (162), Death by euthanasia (161), Weight loss (146), Diarrhoea (108). Outcome, 579 coded reports: Outcome Unknown leads at 38.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.