Trilostane

15,369 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

15,369

Total Reports

1,661

Deaths Reported

1080.0%

Death Rate

Active Ingredients

Trilostane

Administration Routes

OralUnknownOtherTopicalTransdermalOphthalmic

Species Affected

Dog 15,087

Unknown 222

Human 46

Cat 12

Horse 1

Other 1

Most Affected Breeds

Retriever - Labrador 1,099

Shih Tzu 803

Chihuahua 718

Crossbred Canine/dog 692

Beagle 681

Terrier - Boston 646

Maltese 624

Terrier - Yorkshire 539

Dog (unknown) 505

Dachshund - Miniature 468

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 2,678

Vomiting 2,547

Elevated serum alkaline phosphatase (SAP) 2,413

Hyperkalaemia 2,292

Weight loss 2,057

Elevated alanine aminotransferase (ALT) 1,902

Underdose 1,901

Diarrhoea 1,857

INEFFECTIVE, CUSHINGS 1,584

Decreased appetite 1,555

Elevated blood urea nitrogen (BUN) 1,414

Anorexia 1,351

Outcome Breakdown

Outcome Unknown

8,923 (59.7%)

Recovered/Normal

2,412 (16.1%)

Ongoing

1,844 (12.3%)

Euthanized

1,173 (7.8%)

Died

491 (3.3%)

Recovered with Sequela

111 (0.7%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.