Trenbolone Acetate;Estradiol Benzoate

Verify with FDA CVM →

212 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
212
Total Reports
55
Deaths Reported
2590.0%
Death Rate

Active Ingredients

Trenbolone Acetate;Estradiol Benzoate

Administration Routes

UnknownSubcutaneous

Species Affected

Cattle 170
Unknown 40
Human 2

Most Affected Breeds

Mixed (Cattle) 129
Unknown 42
Holstein-Friesian also known as Holstein 26
Aberdeen Angus 8
Crossbred Bovine/Cattle 2
Charolais 1
Limousin 1
Cattle (unknown) 1
Corriente 1
Cattle (other) 1

Most Reported Reactions

Increased sexual interest 70
Death 38
Sexual disorder NOS (see 'Reproductive' for named sexual disorders) 28
Implant, Abnormal 18
Increased weight 13
Lack of efficacy - NOS 12
Implant site abscess 8
Musculoskeletal disorder NOS 7
Rectal prolapse 7
Device Defective NOS 7
Aggression 7
Anaphylactic-type reaction 7

Outcome Breakdown

Outcome Unknown
121 (55.5%)
Died
51 (23.4%)
Recovered/Normal
24 (11.0%)
Recovered with Sequela
8 (3.7%)
Euthanized
7 (3.2%)
Ongoing
7 (3.2%)

Data Summary

Metric Value
Total adverse event reports 212
Reports involving death 55
Case-fatality rate (reported events) 2590.0%
Distinct species in reports 3
Distinct breeds in reports 10
Distinct reactions reported 20
Active ingredients on file 1

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.

Trenbolone Acetate;Estradiol Benzoate Adverse Event Insights

The FDA Center for Veterinary Medicine database currently holds 212 adverse event reports referencing Trenbolone Acetate;Estradiol Benzoate, including 55 reports in which the animal died — a 2590.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Trenbolone Acetate;Estradiol Benzoate. Reported administration routes include Unknown, Subcutaneous. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.

The species most frequently named in Trenbolone Acetate;Estradiol Benzoate reports are Cattle (170 reports), Unknown (40 reports), Human (2 reports), with Cattle accounting for the largest share. Within those species, Mixed (Cattle) (129), Unknown (42), Holstein-Friesian also known as Holstein (26) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.

The most commonly reported clinical signs associated with Trenbolone Acetate;Estradiol Benzoate are Increased sexual interest (70), Death (38), Sexual disorder NOS (see 'Reproductive' for named sexual disorders) (28), Implant, Abnormal (18). Of the 218 reports with a coded outcome, Outcome Unknown is the leading category at 55.5%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Trenbolone Acetate;Estradiol Benzoate.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial