Drug profile

The FDA adverse-event record for Trenbolone Acetate & Estradiol

16 FDA reports name Trenbolone Acetate & Estradiol, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2061 of 2,679
by report volume (all drugs)
16
adverse-event reports
62.5%
death-coded share
Cattle
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Trenbolone Acetate & Estradiol ranks #1995 of 2679 by total reports (16). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1995
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Trenbolone Acetate & Estradiol has 16 reports now versus 16 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Trenbolone Acetate & Estradiol changes

Signature read: Trenbolone Acetate & Estradiol's 62.5% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
16
Total Reports
10
Deaths Reported
62.5%
Death-coded share of reports

Active Ingredients

Trenbolone Acetate & Estradiol

Administration Routes

UnknownSubcutaneous

Species Affected

Cattle 16

Most Affected Breeds

Mixed (Cattle) 9
Cattle (other) 3
Crossbred Bovine/Cattle 3
Cattle (unknown) 1

Most Reported Reactions

Death 6
Lack of efficacy - NOS 5
Lack of efficacy (bacteria) - NOS 3
Anaphylactic-type reaction 3
Death by euthanasia 2
Lack of efficacy 2
PR-LUNG(S), LESION(S) 1
DEATH-TREATMENT FAILURE 1
CULTURE/TITER DATA ABNORMAL 1
Unrelated death 1
Abscess NOS 1
Weight loss 1

Outcome Breakdown

Died
8 (38.1%)
Outcome Unknown
6 (28.6%)
Recovered/Normal
3 (14.3%)
Euthanized
2 (9.5%)
Ongoing
1 (4.8%)
Recovered with Sequela
1 (4.8%)

Trenbolone Acetate & Estradiol: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Trenbolone Acetate & Estradiol (#2061 of 2,679 by report volume); death-coded 62.5%. PlainBreed drug row · death-coded share stamp 62.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →