Drug profile

The FDA adverse-event record for Toceranib Phosphate

1,118 FDA reports name Toceranib Phosphate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#166 of 2,679
by report volume (all drugs)
1,118
adverse-event reports
12.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Toceranib Phosphate ranks #166 of 2679 by total reports (1,118) and #440 of 1130 by death-coded share (12.5%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#166
This drug, reports of 2679
#440
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Toceranib Phosphate has 1,118 reports now versus 1,110 in that prior snapshot: 8 more (0.7%).

Report change
+8
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Toceranib Phosphate changes

Signature read: death-coded report count at 140 is the most distinctive stamp on Toceranib Phosphate's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,118
Total Reports
140
Deaths Reported
12.5%
Death-coded share of reports

Active Ingredients

Toceranib Phosphate

Administration Routes

OralUnknownTopicalOtherSubconjunctivalRectalOphthalmic

Species Affected

Dog 914
Cat 98
Unknown 80
Human 25
Other Rodents 1

Most Affected Breeds

Retriever - Labrador 108
Unknown 105
Dog (unknown) 80
Retriever - Golden 48
Domestic Shorthair 48
Boxer (German Boxer) 41
Mixed (Dog) 39
Terrier - Bull - American Pit 33
Crossbred Canine/dog 31
Pug 30

Most Reported Reactions

Diarrhoea 195
Vomiting 172
Anorexia 132
Lack of efficacy - NOS 88
Lethargy (see also Central nervous system depression in 'Neurological') 86
Anaemia NOS 85
Lameness 82
Weight loss 82
Death by euthanasia 80
Neutropenia 78
Leucopenia NOS 72
Elevated serum alkaline phosphatase (SAP) 71

Outcome Breakdown

Ongoing
522 (56.0%)
Outcome Unknown
163 (17.5%)
Recovered/Normal
106 (11.4%)
Died
80 (8.6%)
Euthanized
61 (6.5%)

Toceranib Phosphate: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Toceranib Phosphate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (1,118 here).

Similar death-coded share

Nearest other drugs by death-coded share (12.5% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Toceranib Phosphate (#166 of 2,679 by report volume); death-coded 12.5%. PlainBreed drug row · death-coded report count stamp 140 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →