Drug profile

The FDA adverse-event record for Tiletamine+Zolazepam

15 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Tiletamine+Zolazepam. See the species affected, top reactions, and outcomes below.

15
adverse-event reports
26.7%
death-coded share
Cat
most-reported species
4
Not eating - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
4
Deaths Reported
26.7%
Death Rate

Active Ingredients

Tiletamine+Zolazepam

Administration Routes

UnknownParenteralIntravenousOtherIntramuscular

Species Affected

Cat 14
Dog 1

Most Affected Breeds

Domestic Shorthair 8
Cat (unknown) 3
Crossbred Feline/cat 1
Poodle (unspecified) 1
Domestic Mediumhair 1
Siamese 1

Most Reported Reactions

Not eating 4
Hyperactivity 4
Dysphoria 4
Death by euthanasia 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Death 2
Elevated temperature 2
Hypotension 2
Lack of efficacy - NOS 1
Recovery prolonged 1
Incorrect route of drug administration 1
Vomiting 1

Outcome Breakdown

Outcome Unknown
5 (33.3%)
Recovered/Normal
5 (33.3%)
Euthanized
2 (13.3%)
Died
2 (13.3%)
Ongoing
1 (6.7%)

Tiletamine+Zolazepam Adverse Event Insights

15 reports name Tiletamine+Zolazepam; 4 recorded a death outcome (26.7% of reported events, not a population-level mortality rate). Active ingredient: Tiletamine+Zolazepam. Administration routes: Unknown, Parenteral, Intravenous, Other.

By species: Cat (14 reports), Dog (1 reports). By breed: Domestic Shorthair (8), Cat (unknown) (3), Crossbred Feline/cat (1).

Leading clinical signs: Not eating (4), Hyperactivity (4), Dysphoria (4), Death by euthanasia (2). Outcome, 15 coded reports: Outcome Unknown leads at 33.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.