Drug profile

The FDA adverse-event record for Tiletamine Hcl & Zolazepam Hcl)

15 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Tiletamine Hcl & Zolazepam Hcl). See the species affected, top reactions, and outcomes below.

15
adverse-event reports
33.3%
death-coded share
Dog
most-reported species
2
Circling - neurological disorder (see also 'Behavioural disorders') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
5
Deaths Reported
33.3%
Death Rate

Active Ingredients

Tiletamine Hcl & Zolazepam Hcl)

Administration Routes

UnknownIntramuscularIntravenousSubcutaneous

Species Affected

Dog 9
Cat 6

Most Affected Breeds

Dog (unknown) 3
Cat (other) 3
Retriever - Golden 2
Domestic Shorthair 2
Retriever - Labrador 1
Mixed (Dog) 1
Spaniel (unspecified) 1
Bulldog 1
Domestic Longhair 1

Most Reported Reactions

Circling - neurological disorder (see also 'Behavioural disorders') 2
Hernia NOS 2
Surgical site disorder 2
Fever 2
Sudden death 2
Sedation 1
Bradycardia 1
Apnoea 1
Depressed ocular reflex 1
Laboured breathing 1
Loose stool 1
Limb weakness 1

Outcome Breakdown

Recovered/Normal
6 (40.0%)
Ongoing
4 (26.7%)
Died
3 (20.0%)
Euthanized
2 (13.3%)

Tiletamine Hcl & Zolazepam Hcl) Adverse Event Insights

15 reports name Tiletamine Hcl & Zolazepam Hcl); 5 recorded a death outcome (33.3% of reported events, not a population-level mortality rate). Active ingredient: Tiletamine Hcl & Zolazepam Hcl). Administration routes: Unknown, Intramuscular, Intravenous, Subcutaneous.

By species: Dog (9 reports), Cat (6 reports). By breed: Dog (unknown) (3), Cat (other) (3), Retriever - Golden (2).

Leading clinical signs: Circling - neurological disorder (see also 'Behavioural disorders') (2), Hernia NOS (2), Surgical site disorder (2), Fever (2). Outcome, 15 coded reports: Recovered/Normal leads at 40.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.