Drug profile

The FDA adverse-event record for Tiletamine Hcl; Zolazapam Hcl

523 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Tiletamine Hcl; Zolazapam Hcl. See the species affected, top reactions, and outcomes below.

523
adverse-event reports
22.0%
death-coded share
Dog
most-reported species
94
INEFFECTIVE, ANESTHESIA - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
523
Total Reports
115
Deaths Reported
22.0%
Death Rate

Active Ingredients

Tiletamine Hcl; Zolazapam Hcl

Administration Routes

IntramuscularUnknownIntravenousSubcutaneousOtherOphthalmic

Species Affected

Dog 246
Cat 226
Unknown 33
Human 8
Pig 4
White tailed deer 2
Primate 2
Bear 1
Moose 1

Most Affected Breeds

Domestic Shorthair 112
Dog (unknown) 77
Unknown 45
Cat (unknown) 44
Cat (other) 29
Retriever - Labrador 23
Domestic Longhair 19
Shih Tzu 8
Boxer (German Boxer) 8
Domestic Mediumhair 7

Most Reported Reactions

INEFFECTIVE, ANESTHESIA 94
Death 67
Lack of efficacy - NOS 54
Cardiac arrest 41
INEFFECTIVE, SEDATION 35
Incorrect route of drug administration 35
Underdose 34
Lethargy (see also Central nervous system depression in 'Neurological') 32
Recovery prolonged 31
Vomiting 29
Death by euthanasia 27
Behavioural disorder NOS 27

Outcome Breakdown

Recovered/Normal
213 (42.4%)
Ongoing
109 (21.7%)
Died
70 (13.9%)
Outcome Unknown
64 (12.7%)
Euthanized
45 (9.0%)
Recovered with Sequela
1 (0.2%)

Tiletamine Hcl; Zolazapam Hcl Adverse Event Insights

523 reports name Tiletamine Hcl; Zolazapam Hcl; 115 recorded a death outcome (22.0% of reported events, not a population-level mortality rate). Active ingredient: Tiletamine Hcl; Zolazapam Hcl. Administration routes: Intramuscular, Unknown, Intravenous, Subcutaneous.

By species: Dog (246 reports), Cat (226 reports), Unknown (33 reports). By breed: Domestic Shorthair (112), Dog (unknown) (77), Unknown (45).

Leading clinical signs: INEFFECTIVE, ANESTHESIA (94), Death (67), Lack of efficacy - NOS (54), Cardiac arrest (41). Outcome, 502 coded reports: Recovered/Normal leads at 42.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.