Drug profile

The FDA adverse-event record for Tiletamine Hcl And Zolazepam Hcl

34 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Tiletamine Hcl And Zolazepam Hcl. See the species affected, top reactions, and outcomes below.

34
adverse-event reports
44.1%
death-coded share
Dog
most-reported species
16
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
34
Total Reports
15
Deaths Reported
44.1%
Death Rate

Active Ingredients

Tiletamine Hcl And Zolazepam Hcl

Administration Routes

IntramuscularUnknownIntravenousParenteralSubcutaneous

Species Affected

Dog 18
Cat 15
Unknown 1

Most Affected Breeds

Cat (unknown) 9
Dog (unknown) 9
Domestic Shorthair 6
Crossbred Canine/dog 1
Unknown 1
Basenji 1
Shepherd Dog - German 1
Spaniel (unspecified) 1
Poodle - Standard 1
Bulldog 1

Most Reported Reactions

Lack of efficacy - NOS 16
Death by euthanasia 8
Hyperthermia 4
Unrelated death 4
Hypothermia 2
Vomiting 2
Sudden death 2
Death 2
Immediate pain upon injection 2
INEFFECTIVE, EUTHANASIA 1
Mydriasis 1
Neurological signs NOS 1

Outcome Breakdown

Recovered/Normal
12 (36.4%)
Euthanized
11 (33.3%)
Outcome Unknown
5 (15.2%)
Died
4 (12.1%)
Ongoing
1 (3.0%)

Tiletamine Hcl And Zolazepam Hcl Adverse Event Insights

34 reports name Tiletamine Hcl And Zolazepam Hcl; 15 recorded a death outcome (44.1% of reported events, not a population-level mortality rate). Active ingredient: Tiletamine Hcl And Zolazepam Hcl. Administration routes: Intramuscular, Unknown, Intravenous, Parenteral.

By species: Dog (18 reports), Cat (15 reports), Unknown (1 reports). By breed: Cat (unknown) (9), Dog (unknown) (9), Domestic Shorthair (6).

Leading clinical signs: Lack of efficacy - NOS (16), Death by euthanasia (8), Hyperthermia (4), Unrelated death (4). Outcome, 33 coded reports: Recovered/Normal leads at 36.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.