Drug profile

The FDA adverse-event record for Tiamulin

117 FDA reports name Tiamulin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#722 of 2,679
by report volume (all drugs)
117
adverse-event reports
65.0%
death-coded share
Pig
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Tiamulin ranks #717 of 2679 by total reports (117) and #37 of 1130 by death-coded share (65.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#717
This drug, reports of 2679
#37
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Tiamulin has 117 reports now versus 114 in that prior snapshot: 3 more (2.6%).

Report change
+3
Death-coded reports
+1
Death-coded share
−0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Tiamulin changes

Signature read: Tiamulin's 65.0% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
117
Total Reports
76
Deaths Reported
65.0%
Death-coded share of reports

Active Ingredients

Tiamulin

Administration Routes

OralUnknown

Species Affected

Pig 83
Unknown 22
Chicken 4
Turkey 2
Cattle 2
Dog 2
Goat 1
Horse 1

Most Affected Breeds

Pig (unknown) 56
Unknown 22
Crossbred Porcine/Pig 17
Mixed (Pig) 4
Chicken (unknown) 3
Pig (other) 3
Turkey (unknown) 2
Commercial hybrid 2
Cattle (other) 1
Cattle (unknown) 1

Most Reported Reactions

Death 68
Recumbency 16
Vocalisation 16
Lateral recumbency 9
Lameness 9
Death by euthanasia 8
Other abnormal test result NOS 8
Diarrhoea 8
NT - Abnormal necropsy finding NOS 7
Pneumonia 7
Lethargy (see also Central nervous system depression in 'Neurological') 7
Cough 6

Outcome Breakdown

Died
73 (50.7%)
Outcome Unknown
35 (24.3%)
Recovered/Normal
13 (9.0%)
Ongoing
13 (9.0%)
Euthanized
10 (6.9%)

Tiamulin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Tiamulin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Tiamulin (#722 of 2,679 by report volume); death-coded 65.0%. PlainBreed drug row · death-coded share stamp 65.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →