Drug profile

The FDA adverse-event record for Thyroid Supplement

134 FDA reports name Thyroid Supplement, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#671 of 2,679
by report volume (all drugs)
134
adverse-event reports
14.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Thyroid Supplement ranks #667 of 2679 by total reports (134) and #366 of 1130 by death-coded share (14.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#667
This drug, reports of 2679
#366
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Thyroid Supplement has 134 reports now versus 130 in that prior snapshot: 4 more (3.1%).

Report change
+4
Death-coded reports
+0
Death-coded share
−0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Thyroid Supplement changes

Signature read: death-coded report count at 20 is the most distinctive stamp on Thyroid Supplement's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
134
Total Reports
20
Deaths Reported
14.9%
Death-coded share of reports

Active Ingredients

Thyroid Supplement

Administration Routes

OralUnknown

Species Affected

Dog 133
Cat 1

Most Affected Breeds

Retriever - Labrador 16
Retriever - Golden 12
Crossbred Canine/dog 8
Beagle 7
Boxer (German Boxer) 7
Terrier (unspecified) 5
Shepherd Dog - German 4
Dog (unknown) 4
Pug 3
Rottweiler 3

Most Reported Reactions

Weight loss 20
Diarrhoea 18
Lack of efficacy - NOS 18
Death by euthanasia 17
Vomiting 15
Decreased appetite 14
Lethargy (see also Central nervous system depression in 'Neurological') 13
Elevated alanine aminotransferase (ALT) 12
INEFFECTIVE, LOSS OF EFFECT 11
Elevated serum alkaline phosphatase (SAP) 10
Decreased urine concentration 10
Proteinuria 9

Outcome Breakdown

Ongoing
52 (38.8%)
Outcome Unknown
37 (27.6%)
Recovered/Normal
25 (18.7%)
Euthanized
17 (12.7%)
Died
3 (2.2%)

Thyroid Supplement: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Thyroid Supplement, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Thyroid Supplement (#671 of 2,679 by report volume); death-coded 14.9%. PlainBreed drug row · death-coded report count stamp 20 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →