Drug profile

The FDA adverse-event record for Thyroid Medication

107 FDA reports name Thyroid Medication, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#759 of 2,679
by report volume (all drugs)
107
adverse-event reports
17.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Thyroid Medication ranks #755 of 2679 by total reports (107) and #281 of 1130 by death-coded share (17.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#755
This drug, reports of 2679
#281
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Thyroid Medication has 107 reports now versus 106 in that prior snapshot: 1 more (0.9%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Thyroid Medication changes

Signature read: death-coded report count at 19 is the most distinctive stamp on Thyroid Medication's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
107
Total Reports
19
Deaths Reported
17.8%
Death-coded share of reports

Active Ingredients

Thyroid Medication

Administration Routes

OralUnknownTopicalSubcutaneous

Species Affected

Dog 97
Cat 7
Human 3

Most Affected Breeds

Retriever - Labrador 17
Shepherd Dog - German 10
Beagle 6
Shih Tzu 5
Domestic Shorthair 5
Boxer (German Boxer) 4
Retriever - Golden 4
Dog (unknown) 4
Unknown 3
Chihuahua 3

Most Reported Reactions

Diarrhoea 17
Vomiting 15
Death by euthanasia 12
Seizure NOS 9
Decreased appetite 9
Polydipsia 8
Lethargy (see also Central nervous system depression in 'Neurological') 8
Ataxia 7
Weight loss 7
Polyuria 7
Not eating 7
Lack of efficacy - NOS 6

Outcome Breakdown

Outcome Unknown
33 (30.8%)
Ongoing
33 (30.8%)
Recovered/Normal
20 (18.7%)
Euthanized
12 (11.2%)
Died
7 (6.5%)
Recovered with Sequela
2 (1.9%)

Thyroid Medication: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Thyroid Medication, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (107 here).

Similar death-coded share

Nearest other drugs by death-coded share (17.8% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Thyroid Medication (#759 of 2,679 by report volume); death-coded 17.8%. PlainBreed drug row · death-coded report count stamp 19 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →