Spinosad/Milbemycin Oxime
269 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
269
Total Reports
3
Deaths Reported
110.0%
Death Rate
Active Ingredients
Spinosad/Milbemycin Oxime
Administration Routes
OralUnknown
Species Affected
Dog 269
Most Affected Breeds
Retriever - Labrador 59
Crossbred Canine/dog 35
Shepherd Dog - German 14
Boxer (German Boxer) 12
Pit Bull 12
Retriever - Golden 11
Beagle 11
Chihuahua 8
Dachshund (unspecified) 6
Collie (unspecified) 5
Most Reported Reactions
INEFFECTIVE, HEARTWORM LARVAE 179
Lack of efficacy - NOS 28
Vomiting 17
Lethargy (see also Central nervous system depression in 'Neurological') 11
Lack of efficacy (endoparasite) - heartworm 11
Underdose 10
Diarrhoea 10
Lack of efficacy (heartworm) 10
Other abnormal test result NOS 8
Pruritus 7
Anorexia 6
Lack of efficacy (endoparasite) - tapeworm 5
Outcome Breakdown
Ongoing
117 (43.5%)
Outcome Unknown
101 (37.5%)
Recovered/Normal
46 (17.1%)
Died
3 (1.1%)
Recovered with Sequela
2 (0.7%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.