Drug profile

The FDA adverse-event record for Spinosad + Milbemycin Oxime

Name: Spinosad + Milbemycin Oxime - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

28 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Spinosad + Milbemycin Oxime. See the species affected, top reactions, and outcomes below.

28
adverse-event reports: 3.6%
death-coded share: Dog
most-reported species: 14
INEFFECTIVE, HEARTWORM LARVAE - top reaction

Compiled by PlainBreed Editorial, Pet Health Editorial Team

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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

3.6%

Death Rate

Active Ingredients

Spinosad + Milbemycin Oxime

Administration Routes

OralUnknown

Species Affected

Dog 28

Most Affected Breeds

Crossbred Canine/dog 4

Retriever - Golden 3

Retriever - Labrador 3

Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2

Shepherd Dog - Australian 2

Dog (unknown) 2

Dachshund - Miniature 1

Collie - Border 1

Brittany 1

Dachshund - Standard Long-haired 1

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 14

Other abnormal test result NOS 3

Diarrhoea 2

Anorexia 2

Weight loss 2

Lack of efficacy (endoparasite) - whipworm 2

Lethargy (see also Central nervous system depression in 'Neurological') 2

Pruritus 2

Lack of efficacy (endoparasite) - tapeworm 2

Underdose 1

Drug dose omission 1

Malaise 1

Outcome Breakdown

Outcome Unknown

10 (35.7%)

Ongoing

9 (32.1%)

Recovered/Normal

8 (28.6%)

Euthanized

1 (3.6%)

Spinosad + Milbemycin Oxime Adverse Event Insights

28 reports name Spinosad + Milbemycin Oxime; 1 recorded a death outcome (3.6% of reported events, not a population-level mortality rate). Active ingredient: Spinosad + Milbemycin Oxime. Administration routes: Oral, Unknown.

By species: Dog (28 reports). By breed: Crossbred Canine/dog (4), Retriever - Golden (3), Retriever - Labrador (3).

Leading clinical signs: INEFFECTIVE, HEARTWORM LARVAE (14), Other abnormal test result NOS (3), Diarrhoea (2), Anorexia (2). Outcome, 28 coded reports: Outcome Unknown leads at 35.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.