Spinosad; Milbemycin Oxime
824 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
824
Total Reports
21
Deaths Reported
250.0%
Death Rate
Active Ingredients
Spinosad; Milbemycin Oxime
Administration Routes
OralUnknownTopicalOtherCutaneous
Species Affected
Dog 733
Unknown 84
Human 4
Other 1
Cat 1
Other Canids 1
Most Affected Breeds
Unknown 89
Dog (unknown) 69
Retriever - Labrador 64
Crossbred Canine/dog 42
Retriever - Golden 35
Chihuahua 35
Shepherd Dog - German 28
Shih Tzu 28
Boxer (German Boxer) 24
Pit Bull 23
Most Reported Reactions
Emesis 259
Vomiting 131
Lethargy (see also Central nervous system depression in 'Neurological') 129
UNPALATABLE 83
Lack of efficacy (ectoparasite) - flea 48
Diarrhoea 43
Lack of efficacy - NOS 42
Behavioural disorder NOS 37
Lack of efficacy (endoparasite) - heartworm 32
Shaking 30
Seizure NOS 29
Emesis (multiple) 27
Outcome Breakdown
Recovered/Normal
413 (55.8%)
Outcome Unknown
214 (28.9%)
Ongoing
61 (8.2%)
Recovered with Sequela
31 (4.2%)
Died
13 (1.8%)
Euthanized
8 (1.1%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.