Spinosad, Milbemycin
3,647 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
3,647
Total Reports
68
Deaths Reported
190.0%
Death Rate
Active Ingredients
Spinosad, Milbemycin
Administration Routes
OralUnknownTopical
Species Affected
Dog 3,506
Unknown 127
Human 9
Cat 3
Other 2
Most Affected Breeds
Crossbred Canine/dog 720
Retriever - Labrador 248
Terrier - Yorkshire 171
Dog (unknown) 169
Unknown 138
Shih Tzu 136
Boxer (German Boxer) 136
Chihuahua 130
Dachshund (unspecified) 105
Poodle (unspecified) 98
Most Reported Reactions
Vomiting 2,279
Depression 635
Lack of efficacy (ectoparasite) - flea 253
Anorexia 236
Diarrhoea 207
Pruritus 173
UNPALATABLE 162
Accidental exposure 139
Trembling 122
Ataxia 108
Convulsion 105
Hypersalivation 72
Outcome Breakdown
Died
67 (62.0%)
Recovered/Normal
21 (19.4%)
Ongoing
8 (7.4%)
Outcome Unknown
8 (7.4%)
Recovered with Sequela
3 (2.8%)
Euthanized
1 (0.9%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.