Spinosad And Milbemycin Oxime
715 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
715
Total Reports
34
Deaths Reported
480.0%
Death Rate
Active Ingredients
Spinosad And Milbemycin Oxime
Administration Routes
OralUnknownTopical
Species Affected
Dog 715
Most Affected Breeds
Retriever - Labrador 139
Shepherd Dog - German 48
Terrier - Bull - American Pit 30
Boxer (German Boxer) 23
Shepherd Dog - Australian 22
Beagle 21
Crossbred Canine/dog 21
Chihuahua 20
Retriever - Golden 18
Shih Tzu 18
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 279
INEFFECTIVE, HEARTWORM LARVAE 88
Lethargy (see also Central nervous system depression in 'Neurological') 73
Vomiting 70
Lack of efficacy - NOS 43
Other abnormal test result NOS 38
Seizure NOS 33
Diarrhoea 32
Elevated alanine aminotransferase (ALT) 29
Anorexia 29
Elevated serum alkaline phosphatase (SAP) 27
Pale mucous membrane 18
Outcome Breakdown
Ongoing
551 (77.0%)
Recovered/Normal
75 (10.5%)
Outcome Unknown
56 (7.8%)
Died
19 (2.7%)
Euthanized
15 (2.1%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.