Drug profile

The FDA adverse-event record for Spinetoram

257 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Spinetoram. See the species affected, top reactions, and outcomes below.

257
adverse-event reports
4.3%
death-coded share
Cat
most-reported species
65
Lack of efficacy (ectoparasite) - flea - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
257
Total Reports
11
Deaths Reported
4.3%
Death Rate

Active Ingredients

Spinetoram

Administration Routes

TopicalUnknownOralOther

Species Affected

Cat 256
Dog 1

Most Affected Breeds

Domestic Shorthair 135
Domestic Longhair 27
Cat (unknown) 26
Siamese 20
Domestic Mediumhair 14
Maine Coon 9
American Shorthair 4
Persian 3
Ragdoll 3
Cat (other) 3

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 65
Vomiting 44
Application site hair loss 32
Lethargy (see also Central nervous system depression in 'Neurological') 30
Lack of efficacy (flea) 26
Lack of efficacy - NOS 19
Pruritus 19
Behavioural disorder NOS 18
Other abnormal test result NOS 13
Emesis 12
Weight loss 11
Lack of efficacy (tapeworm) 11

Outcome Breakdown

Outcome Unknown
139 (54.1%)
Recovered/Normal
51 (19.8%)
Ongoing
50 (19.5%)
Recovered with Sequela
6 (2.3%)
Died
6 (2.3%)
Euthanized
5 (1.9%)

Spinetoram Adverse Event Insights

257 reports name Spinetoram; 11 recorded a death outcome (4.3% of reported events, not a population-level mortality rate). Active ingredient: Spinetoram. Administration routes: Topical, Unknown, Oral, Other.

By species: Cat (256 reports), Dog (1 reports). By breed: Domestic Shorthair (135), Domestic Longhair (27), Cat (unknown) (26).

Leading clinical signs: Lack of efficacy (ectoparasite) - flea (65), Vomiting (44), Application site hair loss (32), Lethargy (see also Central nervous system depression in 'Neurological') (30). Outcome, 257 coded reports: Outcome Unknown leads at 54.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.