Drug profile

The FDA adverse-event record for Sodium Hyaluronate

72 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Sodium Hyaluronate. See the species affected, top reactions, and outcomes below.

72
adverse-event reports
4.2%
death-coded share
Unknown
most-reported species
18
Product syringe issue - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
72
Total Reports
3
Deaths Reported
4.2%
Death Rate

Active Ingredients

Sodium Hyaluronate

Administration Routes

UnknownAuricular (Otic)Intra-ArticularOral

Species Affected

Unknown 49
Horse 16
Dog 7

Most Affected Breeds

Unknown 64
Schnauzer (unspecified) 5
Rottweiler 1
Thoroughbred 1
Warmblood (unspecified) 1

Most Reported Reactions

Product syringe issue 18
No sign 17
Broken components, medical device 9
Joint swelling 7
Lameness 4
Appearance, Abnormal 3
Injection site infection 3
Death by euthanasia 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Device breakage/fracture 2
Joint effusion 2
Injection site swelling 1

Outcome Breakdown

Outcome Unknown
15 (65.2%)
Recovered/Normal
5 (21.7%)
Euthanized
3 (13.0%)

Sodium Hyaluronate Adverse Event Insights

72 reports name Sodium Hyaluronate; 3 recorded a death outcome (4.2% of reported events, not a population-level mortality rate). Active ingredient: Sodium Hyaluronate. Administration routes: Unknown, Auricular (Otic), Intra-Articular, Oral.

By species: Unknown (49 reports), Horse (16 reports), Dog (7 reports). By breed: Unknown (64), Schnauzer (unspecified) (5), Rottweiler (1).

Leading clinical signs: Product syringe issue (18), No sign (17), Broken components, medical device (9), Joint swelling (7). Outcome, 23 coded reports: Outcome Unknown leads at 65.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.