Drug profile

The FDA adverse-event record for Sevoflurane

841 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Sevoflurane. See the species affected, top reactions, and outcomes below.

841
adverse-event reports
19.6%
death-coded share
Dog
most-reported species
120
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
841
Total Reports
165
Deaths Reported
19.6%
Death Rate

Active Ingredients

Sevoflurane

Administration Routes

Respiratory (Inhalation)UnknownNasalOtherIntravenousSubcutaneousEndotrachealTransdermal

Species Affected

Dog 497
Cat 273
Unknown 20
Human 14
Horse 11
Rabbit 5
Guinea Pig 4
Other 3
Ferret 3
Monkey 2

Most Affected Breeds

Domestic Shorthair 130
Unknown 61
Dog (unknown) 56
Retriever - Labrador 40
Cat (unknown) 35
Crossbred Canine/dog 28
Domestic Longhair 24
Chihuahua 22
Domestic (unspecified) 19
Terrier - Yorkshire 19

Most Reported Reactions

Death 120
Vomiting 99
Lethargy (see also Central nervous system depression in 'Neurological') 88
Anorexia 75
Bradycardia 70
Cardiac arrest 64
Not eating 48
Diarrhoea 47
INEFFECTIVE, ANESTHESIA 45
Behavioural disorder NOS 43
Other abnormal test result NOS 40
Hypothermia 40

Outcome Breakdown

Recovered/Normal
261 (36.4%)
Ongoing
195 (27.2%)
Died
129 (18.0%)
Outcome Unknown
94 (13.1%)
Euthanized
36 (5.0%)
Recovered with Sequela
3 (0.4%)

Sevoflurane Adverse Event Insights

841 reports name Sevoflurane; 165 recorded a death outcome (19.6% of reported events, not a population-level mortality rate). Active ingredient: Sevoflurane. Administration routes: Respiratory (Inhalation), Unknown, Nasal, Other.

By species: Dog (497 reports), Cat (273 reports), Unknown (20 reports). By breed: Domestic Shorthair (130), Unknown (61), Dog (unknown) (56).

Leading clinical signs: Death (120), Vomiting (99), Lethargy (see also Central nervous system depression in 'Neurological') (88), Anorexia (75). Outcome, 718 coded reports: Recovered/Normal leads at 36.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.