Drug profile

The FDA adverse-event record for Selenium, Vitamin E

54 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Selenium, Vitamin E. See the species affected, top reactions, and outcomes below.

54
adverse-event reports
37.0%
death-coded share
Cattle
most-reported species
25
Anaphylaxis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
54
Total Reports
20
Deaths Reported
37.0%
Death Rate

Active Ingredients

Selenium, Vitamin E

Administration Routes

SubcutaneousUnknownIntramuscularIntravenous

Species Affected

Cattle 29
Horse 10
Sheep 5
Goat 4
Human 4
Unknown 2

Most Affected Breeds

Holstein-Friesian also known as Holstein 13
Unknown 6
Crossbred Bovine/Cattle 5
Aberdeen Angus 5
Quarter Horse 4
Cattle (unknown) 3
Sheep (unknown) 3
Tennessee Walking Horse 2
Sheep (other) 2
Thoroughbred 2

Most Reported Reactions

Anaphylaxis 25
Death 20
Hypersalivation 8
Collapse (see also 'Cardio-vascular' and 'Systemic disorders') 5
Dyspnoea 5
Injection site swelling 5
Unclassifiable adverse event 5
Recumbency 4
Respiratory distress 4
Tachypnoea 4
Accidental exposure 4
Abortion 3

Outcome Breakdown

Died
20 (90.9%)
Recovered/Normal
2 (9.1%)

Selenium, Vitamin E Adverse Event Insights

54 reports name Selenium, Vitamin E; 20 recorded a death outcome (37.0% of reported events, not a population-level mortality rate). Active ingredient: Selenium, Vitamin E. Administration routes: Subcutaneous, Unknown, Intramuscular, Intravenous.

By species: Cattle (29 reports), Horse (10 reports), Sheep (5 reports). By breed: Holstein-Friesian also known as Holstein (13), Unknown (6), Crossbred Bovine/Cattle (5).

Leading clinical signs: Anaphylaxis (25), Death (20), Hypersalivation (8), Collapse (see also 'Cardio-vascular' and 'Systemic disorders') (5). Outcome, 22 coded reports: Died leads at 90.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.