Drug profile

The FDA adverse-event record for Selegiline Hcl

182 FDA reports name Selegiline Hcl, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#562 of 2,679
by report volume (all drugs)
182
adverse-event reports
3.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Selegiline Hcl ranks #561 of 2679 by total reports (182) and #893 of 1130 by death-coded share (3.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#561
This drug, reports of 2679
#893
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Selegiline Hcl has 182 reports now versus 182 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Selegiline Hcl changes

Signature read: 182 reports place Selegiline Hcl in the upper third of FDA AER volume (#562 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
182
Total Reports
6
Deaths Reported
3.3%
Death-coded share of reports

Active Ingredients

Selegiline Hcl

Administration Routes

OralUnknownOphthalmic

Species Affected

Dog 174
Unknown 6
Cat 2

Most Affected Breeds

Dog (unknown) 19
Retriever - Labrador 14
Maltese 7
Schnauzer - Miniature 6
Shih Tzu 6
Unknown 6
Mixed (Dog) 5
Crossbred Canine/dog 5
Dachshund (unspecified) 5
Pug 4

Most Reported Reactions

INEFFECTIVE, COGNITIVE DYSFUNC 41
Restlessness 20
Vomiting 17
Diarrhoea 16
Panting 15
Lethargy (see also Central nervous system depression in 'Neurological') 14
Agitation 14
Behavioural disorder NOS 13
Seizure NOS 10
Vocalisation 10
Underdose 10
INEFFECTIVE, CUSHINGS 9

Outcome Breakdown

Ongoing
80 (45.5%)
Outcome Unknown
59 (33.5%)
Recovered/Normal
31 (17.6%)
Euthanized
3 (1.7%)
Died
3 (1.7%)

Selegiline Hcl: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Selegiline Hcl, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (182 here).

Similar death-coded share

Nearest other drugs by death-coded share (3.3% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Selegiline Hcl (#562 of 2,679 by report volume); death-coded 3.3%. PlainBreed drug row · report volume stamp 182 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →