Drug profile

The FDA adverse-event record for Selegiline Hcl

178 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Selegiline Hcl. See the species affected, top reactions, and outcomes below.

178
adverse-event reports
3.4%
death-coded share
Dog
most-reported species
41
INEFFECTIVE, COGNITIVE DYSFUNC - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
178
Total Reports
6
Deaths Reported
3.4%
Death Rate

Active Ingredients

Selegiline Hcl

Administration Routes

OralUnknownOphthalmic

Species Affected

Dog 170
Unknown 6
Cat 2

Most Affected Breeds

Dog (unknown) 19
Retriever - Labrador 14
Maltese 7
Schnauzer - Miniature 6
Shih Tzu 6
Unknown 6
Mixed (Dog) 5
Dachshund (unspecified) 5
Pug 4
Shepherd Dog - Australian 4

Most Reported Reactions

INEFFECTIVE, COGNITIVE DYSFUNC 41
Restlessness 20
Diarrhoea 16
Vomiting 16
Panting 15
Lethargy (see also Central nervous system depression in 'Neurological') 14
Behavioural disorder NOS 13
Agitation 13
Vocalisation 10
Seizure NOS 10
Underdose 9
INEFFECTIVE, CUSHINGS 9

Outcome Breakdown

Ongoing
78 (45.3%)
Outcome Unknown
59 (34.3%)
Recovered/Normal
29 (16.9%)
Euthanized
3 (1.7%)
Died
3 (1.7%)

Selegiline Hcl Adverse Event Insights

178 reports name Selegiline Hcl; 6 recorded a death outcome (3.4% of reported events, not a population-level mortality rate). Active ingredient: Selegiline Hcl. Administration routes: Oral, Unknown, Ophthalmic.

By species: Dog (170 reports), Unknown (6 reports), Cat (2 reports). By breed: Dog (unknown) (19), Retriever - Labrador (14), Maltese (7).

Leading clinical signs: INEFFECTIVE, COGNITIVE DYSFUNC (41), Restlessness (20), Diarrhoea (16), Vomiting (16). Outcome, 172 coded reports: Ongoing leads at 45.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.