Drug profile

The FDA adverse-event record for Selegiline

134 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Selegiline. See the species affected, top reactions, and outcomes below.

134
adverse-event reports
14.2%
death-coded share
Dog
most-reported species
16
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
134
Total Reports
19
Deaths Reported
14.2%
Death Rate

Active Ingredients

Selegiline

Administration Routes

OralUnknownTransdermal

Species Affected

Dog 129
Cat 2
Unknown 2
Human 1

Most Affected Breeds

Crossbred Canine/dog 22
Terrier - Jack Russell 7
Terrier - Yorkshire 6
Beagle 6
Bichon Frise 5
Maltese 5
Terrier - Boston 4
Dog (unknown) 4
Lhasa Apso 4
Shih Tzu 4

Most Reported Reactions

Vomiting 16
INEFFECTIVE, COGNITIVE DYSFUNC 15
Death by euthanasia 14
Depression 12
Diarrhoea 11
Anorexia 11
Hyperactivity 9
Ataxia 9
Restlessness 8
Elevated alanine aminotransferase (ALT) 8
Seizure NOS 8
Elevated blood urea nitrogen (BUN) 7

Outcome Breakdown

Ongoing
19 (30.2%)
Outcome Unknown
17 (27.0%)
Died
10 (15.9%)
Euthanized
9 (14.3%)
Recovered/Normal
8 (12.7%)

Selegiline Adverse Event Insights

134 reports name Selegiline; 19 recorded a death outcome (14.2% of reported events, not a population-level mortality rate). Active ingredient: Selegiline. Administration routes: Oral, Unknown, Transdermal.

By species: Dog (129 reports), Cat (2 reports), Unknown (2 reports). By breed: Crossbred Canine/dog (22), Terrier - Jack Russell (7), Terrier - Yorkshire (6).

Leading clinical signs: Vomiting (16), INEFFECTIVE, COGNITIVE DYSFUNC (15), Death by euthanasia (14), Depression (12). Outcome, 63 coded reports: Ongoing leads at 30.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.