Drug profile

The FDA adverse-event record for Selegiline

136 FDA reports name Selegiline, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#660 of 2,679
by report volume (all drugs)
136
adverse-event reports
14.7%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Selegiline ranks #657 of 2679 by total reports (136) and #374 of 1130 by death-coded share (14.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#657
This drug, reports of 2679
#374
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Selegiline has 136 reports now versus 136 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Selegiline changes

Signature read: death-coded report count at 20 is the most distinctive stamp on Selegiline's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
136
Total Reports
20
Deaths Reported
14.7%
Death-coded share of reports

Active Ingredients

Selegiline

Administration Routes

OralUnknownTransdermal

Species Affected

Dog 130
Cat 3
Unknown 2
Human 1

Most Affected Breeds

Crossbred Canine/dog 22
Terrier - Jack Russell 7
Beagle 6
Terrier - Yorkshire 6
Bichon Frise 5
Maltese 5
Terrier - Boston 4
Dog (unknown) 4
Lhasa Apso 4
Shih Tzu 4

Most Reported Reactions

Vomiting 16
INEFFECTIVE, COGNITIVE DYSFUNC 15
Death by euthanasia 14
Depression 12
Diarrhoea 11
Anorexia 11
Hyperactivity 9
Ataxia 9
Restlessness 8
Elevated alanine aminotransferase (ALT) 8
Seizure NOS 8
Elevated blood urea nitrogen (BUN) 7

Outcome Breakdown

Ongoing
19 (29.2%)
Outcome Unknown
18 (27.7%)
Died
11 (16.9%)
Euthanized
9 (13.8%)
Recovered/Normal
8 (12.3%)

Selegiline: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Selegiline, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar report volume

Nearest other drugs by FDA report count (136 here).

Similar death-coded share

Nearest other drugs by death-coded share (14.7% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Selegiline (#660 of 2,679 by report volume); death-coded 14.7%. PlainBreed drug row · death-coded report count stamp 20 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →