Drug profile

The FDA adverse-event record for Selamectin,Sarolaner

81 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Selamectin,Sarolaner. See the species affected, top reactions, and outcomes below.

81
adverse-event reports
1.2%
death-coded share
Cat
most-reported species
16
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
81
Total Reports
1
Deaths Reported
1.2%
Death Rate

Active Ingredients

Selamectin,Sarolaner

Administration Routes

TopicalUnknownOral

Species Affected

Cat 79
Dog 2

Most Affected Breeds

Domestic Shorthair 52
Domestic Longhair 6
Cat (unknown) 5
Maine Coon 5
Domestic Mediumhair 4
Cat (other) 2
Ragdoll 2
American Shorthair 2
Pug 1
Russian 1

Most Reported Reactions

Vomiting 16
Lack of efficacy (endoparasite) - tapeworm 16
Weight loss 10
Decreased appetite 9
Lethargy (see also Central nervous system depression in Neurological) 8
Lethargy (see also Central nervous system depression in 'Neurological') 7
Hiding 6
Anorexia 6
Ataxia 6
Lack of efficacy - NOS 6
Behavioural disorder NOS 5
Diarrhoea 5

Outcome Breakdown

Outcome Unknown
43 (53.1%)
Ongoing
21 (25.9%)
Recovered/Normal
16 (19.8%)
Died
1 (1.2%)

Selamectin,Sarolaner Adverse Event Insights

81 reports name Selamectin,Sarolaner; 1 recorded a death outcome (1.2% of reported events, not a population-level mortality rate). Active ingredient: Selamectin,Sarolaner. Administration routes: Topical, Unknown, Oral.

By species: Cat (79 reports), Dog (2 reports). By breed: Domestic Shorthair (52), Domestic Longhair (6), Cat (unknown) (5).

Leading clinical signs: Vomiting (16), Lack of efficacy (endoparasite) - tapeworm (16), Weight loss (10), Decreased appetite (9). Outcome, 81 coded reports: Outcome Unknown leads at 53.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.