Drug profile

The FDA adverse-event record for Selamectin And Sarolaner

11 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Selamectin And Sarolaner. See the species affected, top reactions, and outcomes below.

11
adverse-event reports
18.2%
death-coded share
Cat
most-reported species
3
Lack of efficacy (endoparasite) - tapeworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
11
Total Reports
2
Deaths Reported
18.2%
Death Rate

Active Ingredients

Selamectin And Sarolaner

Administration Routes

TopicalUnknownOral

Species Affected

Cat 10
Dog 1

Most Affected Breeds

Domestic Shorthair 8
Mastiff 1
Domestic Mediumhair 1
Domestic Longhair 1

Most Reported Reactions

Lack of efficacy (endoparasite) - tapeworm 3
Lateral recumbency 2
Vomiting 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Renal failure 2
Open mouth breathing 1
Inappropriate elimination NOS 1
Hyperthermia 1
Panting 1
Twitching 1
Drooling 1
Pneumothorax 1

Outcome Breakdown

Outcome Unknown
5 (45.5%)
Recovered/Normal
4 (36.4%)
Euthanized
1 (9.1%)
Died
1 (9.1%)

Selamectin And Sarolaner Adverse Event Insights

11 reports name Selamectin And Sarolaner; 2 recorded a death outcome (18.2% of reported events, not a population-level mortality rate). Active ingredient: Selamectin And Sarolaner. Administration routes: Topical, Unknown, Oral.

By species: Cat (10 reports), Dog (1 reports). By breed: Domestic Shorthair (8), Mastiff (1), Domestic Mediumhair (1).

Leading clinical signs: Lack of efficacy (endoparasite) - tapeworm (3), Lateral recumbency (2), Vomiting (2), Lethargy (see also Central nervous system depression in 'Neurological') (2). Outcome, 11 coded reports: Outcome Unknown leads at 45.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.