Drug profile

The FDA adverse-event record for Sarolaner,Moxidectin,Pyrantel

671 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Sarolaner,Moxidectin,Pyrantel. See the species affected, top reactions, and outcomes below.

671
adverse-event reports
3.4%
death-coded share
Dog
most-reported species
264
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
671
Total Reports
23
Deaths Reported
3.4%
Death Rate

Active Ingredients

Sarolaner,Moxidectin,Pyrantel

Administration Routes

UnknownOralTransdermalAuricular (Otic)

Species Affected

Dog 670
Cat 1

Most Affected Breeds

Retriever - Labrador 89
Retriever - Golden 46
Shepherd Dog - German 45
Crossbred Canine/dog 35
Pit Bull 25
Chihuahua 22
Shih Tzu 21
Dog (unknown) 21
Shepherd Dog - Australian 20
Siberian Husky 19

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 264
Vomiting 81
Diarrhoea 56
Lack of efficacy (endoparasite) - tapeworm 51
Lethargy (see also Central nervous system depression in Neurological) 45
Other abnormal test result NOS 40
Lack of efficacy (endoparasite) - hookworm 35
Lack of efficacy (bacteria) - Borrelia 31
Seizure NOS 28
Not eating 22
Overdose 21
Behavioural disorder NOS 19

Outcome Breakdown

Outcome Unknown
446 (66.5%)
Ongoing
131 (19.5%)
Recovered/Normal
71 (10.6%)
Died
12 (1.8%)
Euthanized
11 (1.6%)

Sarolaner,Moxidectin,Pyrantel Adverse Event Insights

671 reports name Sarolaner,Moxidectin,Pyrantel; 23 recorded a death outcome (3.4% of reported events, not a population-level mortality rate). Active ingredient: Sarolaner,Moxidectin,Pyrantel. Administration routes: Unknown, Oral, Transdermal, Auricular (Otic).

By species: Dog (670 reports), Cat (1 reports). By breed: Retriever - Labrador (89), Retriever - Golden (46), Shepherd Dog - German (45).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (264), Vomiting (81), Diarrhoea (56), Lack of efficacy (endoparasite) - tapeworm (51). Outcome, 671 coded reports: Outcome Unknown leads at 66.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.