(S)-Methoprene + Permethrin
23 adverse event reports submitted to the FDA
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Data Summary
| Metric | Value |
|---|---|
| Total adverse event reports | 23 |
| Reports involving death | 0 |
| Case-fatality rate (reported events) | 0.0% |
| Distinct species in reports | 2 |
| Distinct breeds in reports | 17 |
| Distinct reactions reported | 20 |
| Active ingredients on file | 1 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.
(S)-Methoprene + Permethrin Adverse Event Insights
The FDA Center for Veterinary Medicine database currently holds 23 adverse event reports referencing (S)-Methoprene + Permethrin, including 0 reports in which the animal died — a 0.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: (S)-Methoprene + Permethrin. Reported administration routes include Topical, Other, Unknown. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.
The species most frequently named in (S)-Methoprene + Permethrin reports are Dog (16 reports), Cat (7 reports), with Dog accounting for the largest share. Within those species, Chinese Crested Dog – Hairless (5), Cat (unknown) (2), Chihuahua (2) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.
The most commonly reported clinical signs associated with (S)-Methoprene + Permethrin are Lack of efficacy (flea) (8), Lack of efficacy (ectoparasite) - flea (7), Panting (3), Lethargy (see also Central nervous system depression in 'Neurological') (2). Of the 23 reports with a coded outcome, Outcome Unknown is the leading category at 65.2%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on (S)-Methoprene + Permethrin.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.