S-Adenosylmethionine + Silybin
179 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
179
Total Reports
17
Deaths Reported
950.0%
Death Rate
Active Ingredients
S-Adenosylmethionine + Silybin
Administration Routes
UnknownOralIntravenousIntraocular
Species Affected
Dog 168
Cat 10
Human 1
Most Affected Breeds
Retriever - Labrador 24
Crossbred Canine/dog 11
Shih Tzu 10
Chihuahua 8
Beagle 8
Spitz - German Pomeranian 7
Domestic Shorthair 7
Maltese 6
Dog (unknown) 5
Chow Chow 5
Most Reported Reactions
Elevated alanine aminotransferase (ALT) 37
Vomiting 33
Diarrhoea 20
Elevated serum alkaline phosphatase (SAP) 17
Elevated blood urea nitrogen (BUN) 15
Elevated liver enzymes 15
Weight loss 15
Lack of efficacy - NOS 14
Other abnormal test result NOS 13
Death by euthanasia 13
Elevated serum alkaline phosphatase (ALP) 12
Loose stool 11
Outcome Breakdown
Outcome Unknown
65 (36.3%)
Ongoing
63 (35.2%)
Recovered/Normal
31 (17.3%)
Euthanized
13 (7.3%)
Died
4 (2.2%)
Recovered with Sequela
3 (1.7%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.