S-Adenosylmethionine
376 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
376
Total Reports
46
Deaths Reported
1220.0%
Death Rate
Active Ingredients
S-Adenosylmethionine
Administration Routes
OralUnknown
Species Affected
Dog 363
Cat 13
Most Affected Breeds
Retriever - Labrador 50
Chihuahua 19
Crossbred Canine/dog 17
Shih Tzu 16
Schnauzer - Miniature 16
Terrier - Yorkshire 15
Maltese 15
Shepherd Dog - German 11
Terrier - Boston 11
Beagle 10
Most Reported Reactions
Vomiting 77
Elevated alanine aminotransferase (ALT) 71
Emesis 59
Lethargy (see also Central nervous system depression in 'Neurological') 55
Elevated serum alkaline phosphatase (SAP) 53
Other abnormal test result NOS 49
Elevated liver enzymes 44
Diarrhoea 42
Anorexia 32
Death by euthanasia 28
Weight loss 27
Elevated total bilirubin 26
Outcome Breakdown
Recovered/Normal
132 (35.1%)
Outcome Unknown
93 (24.7%)
Ongoing
88 (23.4%)
Euthanized
28 (7.4%)
Died
18 (4.8%)
Recovered with Sequela
17 (4.5%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.