Drug profile

The FDA adverse-event record for S-Adenosyl-Methione

37 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference S-Adenosyl-Methione. Species, reactions, and outcomes follow.

#1306 of 2,679
by report volume (all drugs)
37
adverse-event reports
2.7%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, S-Adenosyl-Methione ranks #1300 of 2679 by total reports (37). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1300
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. S-Adenosyl-Methione has 37 reports now versus 36 in that prior snapshot: 1 more (2.8%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to S-Adenosyl-Methione changes

Signature read: S-Adenosyl-Methione's 2.7% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
37
Total Reports
1
Deaths Reported
2.7%
Death-coded share of reports

Active Ingredients

S-Adenosyl-Methione

Administration Routes

OralUnknown

Species Affected

Dog 37

Most Affected Breeds

Retriever - Labrador 8
Schnauzer - Miniature 3
Shih Tzu 2
Terrier - Yorkshire 2
Maltese 2
Boxer (German Boxer) 2
Terrier - Boston 1
Terrier - Jack Russell 1
Poodle (unspecified) 1
Saint Bernard Dog 1

Most Reported Reactions

Emesis 11
Vomiting 10
Lack of efficacy - NOS 5
Elevated liver enzymes 4
Elevated alanine aminotransferase (ALT) 3
Diarrhoea 2
Lack of efficacy (endoparasite) - hookworm 2
INEFFECTIVE, ASCARIDS NOS 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
INEFFECTIVE, HEARTWORM LARVAE 2
Weight loss 2
Elevated renal parameters 2

Outcome Breakdown

Recovered/Normal
21 (56.8%)
Ongoing
8 (21.6%)
Outcome Unknown
6 (16.2%)
Died
1 (2.7%)
Recovered with Sequela
1 (2.7%)

S-Adenosyl-Methione: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for S-Adenosyl-Methione (#1306 of 2,679 by report volume); death-coded 2.7%. PlainBreed drug row · death-coded share stamp 2.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →