Drug profile

The FDA adverse-event record for Pyrantel Pamoate + Praziquantel

89 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Pyrantel Pamoate + Praziquantel. See the species affected, top reactions, and outcomes below.

89
adverse-event reports
2.2%
death-coded share
Dog
most-reported species
47
Emesis - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
89
Total Reports
2
Deaths Reported
2.2%
Death Rate

Active Ingredients

Pyrantel Pamoate + Praziquantel

Administration Routes

OralUnknown

Species Affected

Dog 85
Cat 3
Human 1

Most Affected Breeds

Retriever - Labrador 7
Crossbred Canine/dog 5
Shepherd Dog - Australian 5
Terrier - Yorkshire 5
Shih Tzu 4
Schnauzer (unspecified) 3
Terrier (unspecified) 3
Domestic Shorthair 3
Maltese 3
Deutsche Dogge, Great Dane 2

Most Reported Reactions

Emesis 47
Lethargy (see also Central nervous system depression in 'Neurological') 8
Vomiting 8
Lack of efficacy - NOS 6
Lack of efficacy (ectoparasite) - flea 5
Diarrhoea 5
Other abnormal test result NOS 4
Pruritus 4
Itching 4
Seizure NOS 3
Eye disorder NOS (for photophobia see 'neurological') 3
Skin ulcer 3

Outcome Breakdown

Recovered/Normal
59 (66.3%)
Outcome Unknown
16 (18.0%)
Ongoing
10 (11.2%)
Recovered with Sequela
2 (2.2%)
Died
2 (2.2%)

Pyrantel Pamoate + Praziquantel Adverse Event Insights

89 reports name Pyrantel Pamoate + Praziquantel; 2 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). Active ingredient: Pyrantel Pamoate + Praziquantel. Administration routes: Oral, Unknown.

By species: Dog (85 reports), Cat (3 reports), Human (1 reports). By breed: Retriever - Labrador (7), Crossbred Canine/dog (5), Shepherd Dog - Australian (5).

Leading clinical signs: Emesis (47), Lethargy (see also Central nervous system depression in 'Neurological') (8), Vomiting (8), Lack of efficacy - NOS (6). Outcome, 89 coded reports: Recovered/Normal leads at 66.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.