Drug profile

The FDA adverse-event record for Pyrantel Pamoate + Praziquantel

90 FDA reports name Pyrantel Pamoate + Praziquantel, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#820 of 2,679
by report volume (all drugs)
90
adverse-event reports
2.2%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Pyrantel Pamoate + Praziquantel ranks #817 of 2679 by total reports (90) and #971 of 1130 by death-coded share (2.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#817
This drug, reports of 2679
#971
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Pyrantel Pamoate + Praziquantel has 90 reports now versus 89 in that prior snapshot: 1 more (1.1%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

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Signature read: Pyrantel Pamoate + Praziquantel's 2.2% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
90
Total Reports
2
Deaths Reported
2.2%
Death-coded share of reports

Active Ingredients

Pyrantel Pamoate + Praziquantel

Administration Routes

OralUnknown

Species Affected

Dog 86
Cat 3
Human 1

Most Affected Breeds

Retriever - Labrador 8
Crossbred Canine/dog 5
Shepherd Dog - Australian 5
Terrier - Yorkshire 5
Shih Tzu 4
Schnauzer (unspecified) 3
Terrier (unspecified) 3
Domestic Shorthair 3
Maltese 3
Dog (other) 2

Most Reported Reactions

Emesis 47
Lethargy (see also Central nervous system depression in 'Neurological') 8
Vomiting 8
Lack of efficacy - NOS 6
Lack of efficacy (ectoparasite) - flea 5
Diarrhoea 5
Other abnormal test result NOS 4
Pruritus 4
Itching 4
Seizure NOS 3
Eye disorder NOS (for photophobia see 'neurological') 3
Skin ulcer 3

Outcome Breakdown

Recovered/Normal
59 (65.6%)
Outcome Unknown
17 (18.9%)
Ongoing
10 (11.1%)
Recovered with Sequela
2 (2.2%)
Died
2 (2.2%)

Pyrantel Pamoate + Praziquantel: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Pyrantel Pamoate + Praziquantel, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Pyrantel Pamoate + Praziquantel's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Pyrantel Pamoate + Praziquantel (#820 of 2,679 by report volume); death-coded 2.2%. PlainBreed drug row · death-coded share stamp 2.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →