Progesterone;Estradiol Benzoate
102 adverse event reports submitted to the FDA
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Data Summary
| Metric | Value |
|---|---|
| Total adverse event reports | 102 |
| Reports involving death | 29 |
| Case-fatality rate (reported events) | 2840.0% |
| Distinct species in reports | 4 |
| Distinct breeds in reports | 12 |
| Distinct reactions reported | 20 |
| Active ingredients on file | 1 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.
Progesterone;Estradiol Benzoate Adverse Event Insights
The FDA Center for Veterinary Medicine database currently holds 102 adverse event reports referencing Progesterone;Estradiol Benzoate, including 29 reports in which the animal died — a 2840.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredient on file: Progesterone;Estradiol Benzoate. Reported administration routes include Unknown, Subcutaneous. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.
The species most frequently named in Progesterone;Estradiol Benzoate reports are Cattle (74 reports), Unknown (24 reports), Human (3 reports), with Cattle accounting for the largest share. Within those species, Mixed (Cattle) (54), Unknown (27), Holstein-Friesian also known as Holstein (7) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.
The most commonly reported clinical signs associated with Progesterone;Estradiol Benzoate are Death (22), INEFFECTIVE, WEIGHT INC (16), Implant, Abnormal (8), Underfilling, Container (8). Of the 91 reports with a coded outcome, Outcome Unknown is the leading category at 56.0%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Progesterone;Estradiol Benzoate.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.