Drug profile

The FDA adverse-event record for Prednisolone; Trimeprazine Tartrate

817 FDA reports name Prednisolone; Trimeprazine Tartrate, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#212 of 2,679
by report volume (all drugs)
817
adverse-event reports
7.8%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Prednisolone; Trimeprazine Tartrate ranks #212 of 2679 by total reports (817) and #653 of 1130 by death-coded share (7.8%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#212
This drug, reports of 2679
#653
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Prednisolone; Trimeprazine Tartrate has 817 reports now versus 817 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Prednisolone; Trimeprazine Tartrate changes

Signature read: 817 reports place Prednisolone; Trimeprazine Tartrate in the upper third of FDA AER volume (#212 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
817
Total Reports
64
Deaths Reported
7.8%
Death-coded share of reports

Active Ingredients

Prednisolone; Trimeprazine Tartrate

Administration Routes

OralUnknownOphthalmicSubcutaneous

Species Affected

Dog 786
Unknown 25
Cat 4
Human 2

Most Affected Breeds

Retriever - Labrador 79
Shih Tzu 59
Terrier - Yorkshire 42
Chihuahua 33
Unknown 27
Dog (unknown) 27
Retriever - Golden 26
Boxer (German Boxer) 23
Maltese 23
Terrier - Jack Russell 21

Most Reported Reactions

Lack of efficacy - NOS 148
Lethargy (see also Central nervous system depression in 'Neurological') 102
INEFFECTIVE, LOSS OF EFFECT 100
Vomiting 97
Elevated serum alkaline phosphatase (SAP) 83
Other abnormal test result NOS 75
INEFFECTIVE, ATOPY CONTROL 71
Polydipsia 64
Polyuria 58
Diarrhoea 53
Anorexia 53
Elevated alanine aminotransferase (ALT) 44

Outcome Breakdown

Ongoing
496 (62.6%)
Outcome Unknown
119 (15.0%)
Recovered/Normal
112 (14.1%)
Euthanized
35 (4.4%)
Died
29 (3.7%)
Recovered with Sequela
1 (0.1%)

Prednisolone; Trimeprazine Tartrate: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Prednisolone; Trimeprazine Tartrate, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (7.8% here), distinct from the volume row.

What to do with this drug

  • Compare Prednisolone; Trimeprazine Tartrate's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Prednisolone; Trimeprazine Tartrate (#212 of 2,679 by report volume); death-coded 7.8%. PlainBreed drug row · report volume stamp 817 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →