Drug profile

The FDA adverse-event record for Praziquantel,Pyrantel Embonate

30 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Praziquantel,Pyrantel Embonate. See the species affected, top reactions, and outcomes below.

30
adverse-event reports
3.3%
death-coded share
Cat
most-reported species
7
Lack of efficacy (endoparasite) - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
30
Total Reports
1
Deaths Reported
3.3%
Death Rate

Active Ingredients

Praziquantel,Pyrantel Embonate

Administration Routes

OralUnknown

Species Affected

Cat 28
Unknown 1
Dog 1

Most Affected Breeds

Domestic Shorthair 16
Cat (unknown) 3
Domestic Longhair 2
Siamese 2
Persian 2
Maine Coon 1
Domestic (unspecified) 1
Unknown 1
Spitz - German Pomeranian 1
Domestic Mediumhair 1

Most Reported Reactions

Lack of efficacy (endoparasite) - NOS 7
Bloody diarrhoea 7
Vomiting 7
Ataxia 4
Wobbliness 3
Lethargy (see also Central nervous system depression in Neurological) 3
Lack of efficacy (endoparasite) - tapeworm 2
Diarrhoea 2
Unsteady gait 2
Anorexia 2
Lot # and/or Expiration date illegible 1
Suspect counterfeit product 1

Outcome Breakdown

Outcome Unknown
16 (55.2%)
Recovered/Normal
8 (27.6%)
Ongoing
4 (13.8%)
Euthanized
1 (3.4%)

Praziquantel,Pyrantel Embonate Adverse Event Insights

30 reports name Praziquantel,Pyrantel Embonate; 1 recorded a death outcome (3.3% of reported events, not a population-level mortality rate). Active ingredient: Praziquantel,Pyrantel Embonate. Administration routes: Oral, Unknown.

By species: Cat (28 reports), Unknown (1 reports), Dog (1 reports). By breed: Domestic Shorthair (16), Cat (unknown) (3), Domestic Longhair (2).

Leading clinical signs: Lack of efficacy (endoparasite) - NOS (7), Bloody diarrhoea (7), Vomiting (7), Ataxia (4). Outcome, 29 coded reports: Outcome Unknown leads at 55.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.