Drug profile

The FDA adverse-event record for Praziquantel; Moxidectin

169 FDA reports name Praziquantel; Moxidectin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#587 of 2,679
by report volume (all drugs)
169
adverse-event reports
7.7%
death-coded share
Horse
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Praziquantel; Moxidectin ranks #582 of 2679 by total reports (169) and #658 of 1130 by death-coded share (7.7%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#582
This drug, reports of 2679
#658
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Praziquantel; Moxidectin has 169 reports now versus 169 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Praziquantel; Moxidectin changes

Signature read: 169 reports place Praziquantel; Moxidectin in the upper third of FDA AER volume (#587 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
169
Total Reports
13
Deaths Reported
7.7%
Death-coded share of reports

Active Ingredients

Praziquantel; Moxidectin

Administration Routes

OralUnknownTopicalIntraocular

Species Affected

Horse 115
Unknown 35
Dog 15
Human 2
Fish 1
Cat 1

Most Affected Breeds

Unknown 37
Quarter Horse 30
Horse (unknown) 26
Thoroughbred 14
Paint 8
Arab 6
Tennessee Walking Horse 5
Crossbred Equine/horse 3
Mustang 3
Miniature 2

Most Reported Reactions

Colic 25
Lack of efficacy - NOS 18
Ataxia 13
Lethargy (see also Central nervous system depression in 'Neurological') 12
No sign 12
Fever 11
Product syringe issue 11
Difficulty of Use 11
Depression 8
Death by euthanasia 8
INEFFECTIVE, PINWORMS 7
Behavioural disorder NOS 7

Outcome Breakdown

Recovered/Normal
57 (42.5%)
Outcome Unknown
38 (28.4%)
Ongoing
24 (17.9%)
Euthanized
7 (5.2%)
Died
6 (4.5%)
Recovered with Sequela
2 (1.5%)

Praziquantel; Moxidectin: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Praziquantel; Moxidectin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Praziquantel; Moxidectin's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Praziquantel; Moxidectin (#587 of 2,679 by report volume); death-coded 7.7%. PlainBreed drug row · report volume stamp 169 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →