Drug profile

The FDA adverse-event record for Polyvinylpyrrolidone & Levothyroxine Sodium

26 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Polyvinylpyrrolidone & Levothyroxine Sodium. See the species affected, top reactions, and outcomes below.

26
adverse-event reports
11.5%
death-coded share
Dog
most-reported species
6
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
26
Total Reports
3
Deaths Reported
11.5%
Death Rate

Active Ingredients

Polyvinylpyrrolidone & Levothyroxine Sodium

Administration Routes

OralUnknown

Species Affected

Dog 26

Most Affected Breeds

Retriever - Labrador 8
Dog (unknown) 2
Retriever - Golden 2
Collie - Border 1
Terrier - Boston 1
Spaniel - Cocker American 1
Retriever - Chesapeake Bay 1
Terrier - Yorkshire 1
Bulldog 1
Chihuahua 1

Most Reported Reactions

Vomiting 6
Seizure NOS 4
Lethargy (see also Central nervous system depression in 'Neurological') 4
Panting 3
Other abnormal test result NOS 3
Elevated serum alkaline phosphatase (SAP) 3
Hypothyroidism 2
Anorexia 2
Polydipsia 2
Lymphoma 2
Death by euthanasia 2
Hives (see also 'Skin') 2

Outcome Breakdown

Ongoing
14 (53.8%)
Recovered/Normal
8 (30.8%)
Euthanized
2 (7.7%)
Outcome Unknown
1 (3.8%)
Died
1 (3.8%)

Polyvinylpyrrolidone & Levothyroxine Sodium Adverse Event Insights

26 reports name Polyvinylpyrrolidone & Levothyroxine Sodium; 3 recorded a death outcome (11.5% of reported events, not a population-level mortality rate). Active ingredient: Polyvinylpyrrolidone & Levothyroxine Sodium. Administration routes: Oral, Unknown.

By species: Dog (26 reports). By breed: Retriever - Labrador (8), Dog (unknown) (2), Retriever - Golden (2).

Leading clinical signs: Vomiting (6), Seizure NOS (4), Lethargy (see also Central nervous system depression in 'Neurological') (4), Panting (3). Outcome, 26 coded reports: Ongoing leads at 53.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.