Drug profile

The FDA adverse-event record for Plasma

85 FDA reports name Plasma, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#856 of 2,679
by report volume (all drugs)
85
adverse-event reports
72.9%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Plasma ranks #851 of 2679 by total reports (85) and #30 of 1130 by death-coded share (72.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#851
This drug, reports of 2679
#30
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Plasma has 85 reports now versus 85 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Plasma changes

Signature read: Plasma's 72.9% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
85
Total Reports
62
Deaths Reported
72.9%
Death-coded share of reports

Active Ingredients

Plasma

Administration Routes

IntravenousUnknownOphthalmicIntra-Articular

Species Affected

Dog 76
Cat 7
Horse 2

Most Affected Breeds

Retriever - Labrador 13
Domestic Shorthair 6
Bulldog - French 5
Spaniel - King Charles Cavalier 4
Terrier (unspecified) 3
Terrier - Yorkshire 3
Boxer (German Boxer) 3
Terrier - Bull - American Pit 3
Deutsche Dogge, Great Dane 3
Shih Tzu 3

Most Reported Reactions

Vomiting 35
Death by euthanasia 33
Lethargy (see also Central nervous system depression in 'Neurological') 32
Elevated total bilirubin 32
Thrombocytopenia 29
Death 29
Elevated alanine aminotransferase (ALT) 27
Other abnormal test result NOS 25
Leucocytosis NOS 24
Anaemia NOS 24
Elevated serum alkaline phosphatase (SAP) 24
Anorexia 22

Outcome Breakdown

Euthanized
33 (38.4%)
Died
29 (33.7%)
Ongoing
18 (20.9%)
Recovered/Normal
6 (7.0%)

Plasma: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Plasma, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (72.9% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Plasma (#856 of 2,679 by report volume); death-coded 72.9%. PlainBreed drug row · death-coded share stamp 72.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →