Drug profile

The FDA adverse-event record for Pentobarbital/Phenytoin Inj

98 FDA reports name Pentobarbital/Phenytoin Inj, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#788 of 2,679
by report volume (all drugs)
98
adverse-event reports
80.6%
death-coded share
Dog
most-reported species
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Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Pentobarbital/Phenytoin Inj ranks #784 of 2679 by total reports (98) and #24 of 1130 by death-coded share (80.6%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#784
This drug, reports of 2679
#24
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Pentobarbital/Phenytoin Inj has 98 reports now versus 98 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Pentobarbital/Phenytoin Inj changes

Signature read: Pentobarbital/Phenytoin Inj's 80.6% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
98
Total Reports
79
Deaths Reported
80.6%
Death-coded share of reports

Active Ingredients

Pentobarbital/Phenytoin Inj

Administration Routes

IntravenousUnknownSubcutaneousOtherTopicalIntraperitonealRespiratory (Inhalation)OphthalmicIntramuscularOral

Species Affected

Dog 58
Cat 15
Human 11
Unknown 7
Horse 5
Duck 1
Other Birds 1

Most Affected Breeds

Unknown 19
Domestic Shorthair 11
Dog (unknown) 8
Crossbred Canine/dog 7
Shepherd Dog - German 4
Mixed (Dog) 4
Retriever - Golden 4
Retriever - Labrador 3
Shih Tzu 3
Horse (unknown) 2

Most Reported Reactions

INEFFECTIVE, EUTHANASIA 60
Overdose 39
Unrelated death 33
Vocalisation 24
Lack of efficacy - NOS 18
Agitation 10
Death by euthanasia 9
INEFFECTIVE, DELAYED EFFECT 8
Pain NOS 7
Accidental exposure 7
Solution, Abnormal 5
Drug administration error 5

Outcome Breakdown

Euthanized
79 (86.8%)
Ongoing
8 (8.8%)
Recovered/Normal
3 (3.3%)
Outcome Unknown
1 (1.1%)

Pentobarbital/Phenytoin Inj: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Pentobarbital/Phenytoin Inj, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Pentobarbital/Phenytoin Inj's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Pentobarbital/Phenytoin Inj (#788 of 2,679 by report volume); death-coded 80.6%. PlainBreed drug row · death-coded share stamp 80.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →