Drug profile

The FDA adverse-event record for Pentobarbital Sodium And Phenytoin Sodium

40 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Pentobarbital Sodium And Phenytoin Sodium. See the species affected, top reactions, and outcomes below.

40
adverse-event reports
85.0%
death-coded share
Dog
most-reported species
29
Lack of efficacy - NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
40
Total Reports
34
Deaths Reported
85.0%
Death Rate

Active Ingredients

Pentobarbital Sodium And Phenytoin Sodium

Administration Routes

UnknownIntravenous

Species Affected

Dog 24
Cat 7
Horse 4
Human 2
Other 1
Other Rodents 1
Other Mammals 1

Most Affected Breeds

Unknown 27
Dog (unknown) 3
Shepherd Dog - German 2
Cat (unknown) 2
Crossbred Canine/dog 1
Chihuahua 1
Mastiff 1
Great Pyrenees 1
Pony (unspecified) 1
Spaniel - King Charles Cavalier 1

Most Reported Reactions

Lack of efficacy - NOS 29
Death by euthanasia 12
Unrelated death 7
Dyspnoea 3
Product Defect, General 3
Twitching 3
Immediate pain upon injection 3
Agonal breathing 2
Seizure NOS 2
Rigidity 2
Vocalisation 2
Torticollis 2

Outcome Breakdown

Euthanized
34 (85.0%)
Recovered/Normal
4 (10.0%)
Outcome Unknown
2 (5.0%)

Pentobarbital Sodium And Phenytoin Sodium Adverse Event Insights

40 reports name Pentobarbital Sodium And Phenytoin Sodium; 34 recorded a death outcome (85.0% of reported events, not a population-level mortality rate). Active ingredient: Pentobarbital Sodium And Phenytoin Sodium. Administration routes: Unknown, Intravenous.

By species: Dog (24 reports), Cat (7 reports), Horse (4 reports). By breed: Unknown (27), Dog (unknown) (3), Shepherd Dog - German (2).

Leading clinical signs: Lack of efficacy - NOS (29), Death by euthanasia (12), Unrelated death (7), Dyspnoea (3). Outcome, 40 coded reports: Euthanized leads at 85.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.